Publication Name	World Journal of Stem Cells
Manuscript ID	15973
Country	United States

Received	2014-12-19 12:02
Peer-Review Started	2014-12-21 15:02
To Make the First Decision	2015-02-07 14:47
Return for Revision	2015-02-11 19:52
Revised	2015-02-28 11:29
Second Decision	2015-05-04 19:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-05-11 14:14
Articles in Press	2015-05-11 14:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-03 16:15
Publish the Manuscript Online	2015-08-01 15:28

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Neurosciences
Manuscript Type	Review
Article Title	Importance of being Nernst: Synaptic activity and functional relevance in stem cell-derived neurons
Manuscript Source	Invited Manuscript
All Author List	Aaron B Bradford and Patrick M McNutt
Funding Agency and Grant Number
Corresponding Author	Patrick M McNutt, PhD, Cell/Molecular Biology Branch, US Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, Aberdeen Proving Grounds-EA, MD 21010, United States. patrick.m.mcnutt2.civ@mail.mil
Key Words	Synapses; Neurotransmission; In vitro techniques; Induced pluripotent stem cells; Neuronal networks; Neurogenesis; Neural stem cells; Embryonic stem cells; Induced neurons
Core Tip	During stem cell neuronal differentiation, functional synaptogenesis and the emergence of coordinated, networked activity are critical behaviors in confirming that cells have developed into a relevant neuronal population. As the number of stem cell-derived neuron (SCN) models continues to proliferate, the use of specific functional readouts to evaluate SCN maturity will become increasingly important compared to mor-phological or proteomic characterization of neuronal maturation. The review provides diverse options for reliably assaying the development of synaptic neurotransmission in derived neurons and describes the strengths, weaknesses and potential applications of several stem cell-based neuron models.
Publish Date	2015-08-01 15:28
Citation	Bradford AB, McNutt PM. Importance of being Nernst: Synaptic activity and functional relevance in stem cell-derived neurons. World J Stem Cells 2015; 7(6): 899-921
URL	http://www.wjgnet.com/1948-0210/full/v7/i6/899.htm
DOI	http://dx.doi.org/10.4252/wjsc.v7.i6.899

Full Article (PDF)	WJSC-7-899.pdf
Full Article (Word)	WJSC-7-899.doc
Manuscript File	15973-Review.docx
Answering Reviewers	15973-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	15973-Conflict-of-interest statement.pdf
Copyright License Agreement	15973-Copyright assignment.pdf
Video	15973-Video core tip.mp4
Peer-review Report	15973-Peer-review(s).pdf
Scientific Misconduct Check	15973-Scientific misconduct check.pdf
Scientific Editor Work List	15973-Scientific editor work list.pdf