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8/26/2015 1:30:00 PM | Browse: 597 | Download: 2164
Publication Name World Journal of Biological Chemistry
Manuscript ID 16597
Country/Territory United States
Received
2015-01-24 20:45
Peer-Review Started
2015-01-28 17:56
To Make the First Decision
2015-03-06 10:12
Return for Revision
2015-03-11 17:55
Revised
2015-03-25 06:30
Second Decision
2015-06-01 14:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-06-11 16:06
Articles in Press
2015-06-11 16:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-08-12 11:20
Publish the Manuscript Online
2015-08-26 11:07
ISSN 1949-8454 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cardiac & Cardiovascular Systems
Manuscript Type Basic Study
Article Title Effect of paricalcitol and enalapril on renal inflammation/oxidative stress in atherosclerosis
Manuscript Source Invited Manuscript
All Author List Kazim Husain, Edu Suarez, Angel Isidro, Wilfredo Hernandez and Leon Ferder
Funding Agency and Grant Number
Funding Agency Grant Number
Abbott Pharmaceutical, United States
Corresponding Author Kazim Husain, PhD, DABT, Professor, Department of Physiology, Pharmacology and Toxicology, Ponce School of Medicine and Health Sciences, PO Box 7004, Ponce, PR 00732, United States. khusain@psm.edu
Key Words Atherosclerosis; Enalapril; Paricalcitol; Renal inflammation; Oxidative stress
Core Tip Although the protective efficacy of vitamin D and angiotensin converting enzyme inhibitors (ACEIs) have been studied in the cardiovascular system of atherosclerotic mice. However this is the first report to investigate the renal protection by paricalcitol and enalapril, alone or in combination in ApoE-deficient atherosclerotic mice. This innovative study clearly shows that vitamin D, ACEI and their combo ameliorated the renal inflammation and oxidative stress in ApoE-knock out animals by depleting the inflammatory and oxidative stress markers as well as restoring the renal antioxidant defense system in atherosclerotic mice. The combination of paricalcitol and enalapril warrants the clinical usefulness in renal atherosclerotic patients.
Publish Date 2015-08-26 11:07
Citation Husain K, Suarez E, Isidro A, Hernandez W, Ferder L. Effect of paricalcitol and enalapril on renal inflammation/oxidative stress in atherosclerosis. World J Biol Chem 2015; 6(3): 240-248
URL http://www.wjgnet.com/1949-8454/full/v6/i3/240.htm
DOI http://dx.doi.org/10.4331/wjbc.v6.i3.240
Full Article (PDF) WJBC-6-240.pdf
Full Article (Word) WJBC-6-240.doc
Manuscript File 16597-Review.doc
Answering Reviewers 16597-Answering reviewers.pdf
Audio Core Tip 16597-Audio core tip.mp3
Biostatistics Review Certificate 16597-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 16597-Conflict-of-interest statement.pdf
Copyright License Agreement 16597-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 16597-Institutional animal care and use committee statement.pdf
Peer-review Report 16597-Peer-review(s).pdf
Scientific Misconduct Check 16597-Scientific misconduct check.pdf
Scientific Editor Work List 16597-Scientific editor work list.pdf