Publication Name	World Journal of Medical Genetics
Manuscript ID	16605
Country

Received	2015-01-24 20:58
Peer-Review Started	2015-01-27 21:39
First Decision by Editorial Office Director
Return for Revision	2015-03-15 17:43
Revised	2015-04-07 01:13
Publication Fee Transferred
Second Decision by Editor	2015-04-10 18:03
Second Decision by Editor-in-Chief	2015-04-13 16:29
Final Decision by Editorial Office Director	2015-04-20 15:01
Articles in Press	2015-04-20 15:01
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-12 11:02
Publish the Manuscript Online	2015-05-29 08:53

ISSN	2220-3184 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Minireviews
Article Title	Comparison of next generation sequencing-based and methylated DNA immunoprecipitation-based approaches for fetal aneuploidy non-invasive prenatal testing
Manuscript Source	Invited Manuscript
All Author List	Georgia Christopoulou, Elisavet A Papageorgiou, Philippos C Patsalis and Voula Velissariou
Funding Agency and Grant Number
Corresponding Author	Voula Velissariou, PhD, Head of Cytogenetics, AlfaLab Cytogenetics and Molecular Biology Center, Hygeia Group, Anastassiou Str., 115 24 Athens, Greece. voulavel@leto.gr
Key Words	Next generation sequencing; Differential methylation; Epigenetics; Fetal aneuploidy; Methylation dependent immunoprecipitation; Non-invasive prenatal testing
Core Tip	Non-invasive prenatal screening and diagnosis of fetal aneuploidies has been a challenging field for many researchers. Different methodologies have been developed, mainly based on next-generation sequencing and epigenetic modifications. At present, non-invasive prenatal testing services are offered using next generation sequencing-based technologies which have great potential, but currently they present with certain limitations. Epigenetic approaches may overcome some of these limitations and seem to have promising potential for wider applications.
Publish Date	2015-05-29 08:53
Citation	Christopoulou G, Papageorgiou EA, Patsalis PC, Velissariou V. Comparison of next generation sequencing-based and methylated DNA immunoprecipitation-based approaches for fetal aneuploidy non-invasive prenatal testing. World J Med Genet 2015; 5(2): 23-27
URL	http://www.wjgnet.com/2220-3184/full/v5/i2/23.htm
DOI	http://dx.doi.org/10.5496/wjmg.v5.i2.23

Full Article (PDF)	WJMG-5-23.pdf
Full Article (Word)	WJMG-5-23.doc
Manuscript File	16605-Review.docx
Answering Reviewers	16605-Answering reviewers.pdf
Audio Core Tip	16605-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16605-Conflict-of-interest statement.pdf
Copyright License Agreement	16605-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	16605-Language certificate.pdf
Peer-review Report	16605-Peer-review(s).pdf
Scientific Misconduct Check	16605-Scientific misconduct check.pdf
Scientific Editor Work List	16605-Scientific editor work list.pdf