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8/26/2015 1:30:00 PM | Browse: 580 | Download: 2264
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Received |
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2015-02-03 09:38 |
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2015-04-10 16:39 |
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2015-04-15 08:56 |
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2015-05-06 21:42 |
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2015-06-01 08:46 |
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Accepted by Journal Editor-in-Chief |
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2015-06-11 15:52 |
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Articles in Press |
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2015-06-11 15:52 |
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Typeset the Manuscript |
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2015-08-13 15:32 |
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Publish the Manuscript Online |
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2015-08-26 11:07 |
| ISSN |
1949-8454 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemical Research Methods |
| Manuscript Type |
Basic Study |
| Article Title |
Characterization of two alkyl hydroperoxide reductase C homologs alkyl hydroperoxide reductase C_H1 and alkyl hydroperoxide reductase C_H2 in Bacillus subtilis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mee-Kyung Cha, Yoo-Jeen Bae, Kyu-Jeong Kim, Byung-Joon Park and Il-Han Kim |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Basic Science Research Program through the Korea Research Foundation Grant funded by the Ministry of Education, Science, and Technology |
NRF-2011-0008913 |
| Paichai University |
to Kim IH and Cha MK |
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| Corresponding Author |
Il-Han Kim, PhD, Department of Life Science and Technology, Daeduk Valley Campus, Paichai University, 11-3 Techno 1-ro, Daejeon, Taejon 305-509, South Korea. ihkim@pcu.ac.kr |
| Key Words |
Cysteine-dependent peroxidase; Thioredoxin; Thiol peroxidase; Peroxiredoxin; Alkyl hydroperoxide; Ortholog; Bacillus subtilis; Oxidative stress |
| Core Tip |
Two alkyl hydroperoxide reductase subunit C (AhpC) homologs (AhpC_H1 and AhpC_H2) were identified by searching the Bacillus subtilis database. Sequence homology and phylogenetic analyses revealed that AhpC_H1 is an ortholog of Escherichia coli (E. coli) AhpC, a representative of bacterial AhpC. AhpC_H1 forms dimers consisting of atypical 2-Cys subunits, while AhpC_H2 behaves like a typical 2-Cys AhpC. These AhpC homologs may perform their respective physiological functions at different peroxide levels. Structural and catalytic differences between the enzymes indicate that AhpC_H1 is not an ortholog of E. coli AhpC, but a novel type of atypical 2-Cys AhpC. |
| Publish Date |
2015-08-26 11:07 |
| Citation |
Cha MK, Bae YJ, Kim KJ, Park BJ, Kim IH. Characterization of two alkyl hydroperoxide reductase C homologs alkyl hydroperoxide reductase C_H1 and alkyl hydroperoxide reductase C_H2 in Bacillus subtilis. World J Biol Chem 2015; 6(3): 249-264 |
| URL |
http://www.wjgnet.com/1949-8454/full/v6/i3/249.htm |
| DOI |
http://dx.doi.org/10.4331/wjbc.v6.i3.249 |
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