Publication Name	World Journal of Gastroenterology
Manuscript ID	17183
Country	Netherlands

Received	2015-02-22 09:46
Peer-Review Started	2015-02-24 09:29
First Decision by Editorial Office Director
Return for Revision	2015-04-16 09:56
Revised	2015-04-29 23:42
Publication Fee Transferred
Second Decision by Editor	2015-06-03 08:02
Second Decision by Editor-in-Chief	2015-06-03 18:19
Final Decision by Editorial Office Director	2015-06-10 16:23
Articles in Press	2015-06-10 16:23
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-29 17:11
Publish the Manuscript Online	2015-08-17 11:15

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Surgery
Manuscript Type	Retrospective Cohort Study
Article Title	Diagnostic value of drain amylase for detecting intrathoracic leakage after esophagectomy
Manuscript Source	Unsolicited Manuscript
All Author List	Gijs HK Berkelmans, Ewout A Kouwenhoven, Boudewijn JJ Smeets, Teus J Weijs, Luis C Silva Corten, Marc J van Det, Grard AP Nieuwenhuijzen and Misha DP Luyer
Funding Agency and Grant Number
Corresponding Author	Misha DP Luyer, MD, PhD, Department of Surgery, Catharina Hospital, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands. misha.luyer@cze.nl
Key Words	Esophageal cancer; Esophageal surgery; Anastomotic leakage; Amylase; Drain fluid
Core Tip	Intrathoracic leakage following esophagectomy is a dreaded complication that requires prompt diagnosis. However, early recognition remains difficult. Elevated drain amylase levels following other types of upper gastrointestinal surgery suggest that the amylase levels may be useful as an early marker for anastomotic leakage following esophagectomy. This study found that the drain amylase levels were higher in patients with proven anastomotic leakage than in patients without anastomotic leakage. This study demonstrates that amylase measurements in drain fluid may be a potential marker for detecting anastomotic leakage after an Ivor-Lewis esophagectomy.
Publish Date	2015-08-17 11:15
Citation	Berkelmans GHK, Kouwenhoven EA, Smeets BJJ, Weijs TJ, Silva Corten LC, van Det MJ, Nieuwenhuijzen GAP, Luyer MDP. Diagnostic value of drain amylase for detecting intrathoracic leakage after esophagectomy. World J Gastroenterol 2015; 21(30): 9118-9125
URL	http://www.wjgnet.com/1007-9327/full/v21/i30/9118.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i30.9118

Full Article (PDF)	WJG-21-9118.pdf
Full Article (Word)	WJG-21-9118.doc