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9/21/2015 7:14:00 PM | Browse: 637 | Download: 2226
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Received |
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2015-04-03 11:53 |
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Peer-Review Started |
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2015-04-03 17:33 |
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To Make the First Decision |
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2015-04-27 15:51 |
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Return for Revision |
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2015-04-28 19:29 |
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Revised |
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2015-06-26 08:17 |
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Second Decision |
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2015-08-13 09:52 |
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Accepted by Journal Editor-in-Chief |
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2015-08-13 22:14 |
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Accepted by Executive Editor-in-Chief |
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2015-08-21 15:58 |
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Articles in Press |
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2015-08-21 15:59 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-09-09 20:55 |
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Publish the Manuscript Online |
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2015-09-20 21:45 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Observational Study |
| Article Title |
Single vs double antiplatelet therapy in acute coronary syndrome: Predictors of bleeding after coronary artery bypass grafting
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Vincenzo Tarzia, Giacomo Bortolussi, Edward Buratto, Carla Paolini, Carlo Dal Lin, Giulio Rizzoli, Tomaso Bottio and Gino Gerosa |
| Funding Agency and Grant Number |
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| Corresponding Author |
Vincenzo Tarzia, MD, Division of Cardiac Surgery, Department of Cardiac, Thoracic and Vascular Sciences, University of Padua Medical School, Via Giustiniani, 2, 35128 Padova, Italy. v.tarzia@gmail.com
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| Key Words |
Platelet inhibitors; Thromboelastometry; Bleeding; Acute coronary syndrome; Coronary artery bypass grafting |
| Core Tip |
To establish the timing of discontinuation of double antiplatelet therapy before coronary artery bypass grafting (CABG), it is crucial to identify predictors of bleeding. We analysed preoperatively classic parameters and thromboelastometry on 100 patients operated for CABG after presenting with acute coronary syndrome, to investigate the contribution of anti-platelet therapy and derangements of pre-operative coagulation status to major bleeding post-CABG. We observed that patients with a low area-under-curve (AUC) value in EXTEM were at a significantly higher risk of bleeding compared to patients with higher AUC, regardless of anti-platelet treatment. This suggests that thrombin generation potential, irrespective of the degree of platelet inhibition, correlates with surgical bleeding.
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| Publish Date |
2015-09-20 21:45 |
| Citation |
Tarzia V, Bortolussi G, Buratto E, Paolini C, Dal Lin C, Rizzoli G, Bottio T, Gerosa G. Single vs double antiplatelet therapy in acute coronary syndrome: Predictors of bleeding after coronary artery bypass grafting. World J Cardiol 2015; 7(9): 571-578 |
| URL |
http://www.wjgnet.com/1949-8462/full/v7/i9/571.htm |
| DOI |
http://dx.doi.org/10.4330/wjc.v7.i9.571 |
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