Publication Name	World Journal of Hepatology
Manuscript ID	18215
Country	Egypt

Received	2015-04-13 09:18
Peer-Review Started	2015-04-15 10:41
First Decision by Editorial Office Director
Return for Revision	2015-06-08 10:14
Revised	2015-06-29 02:49
Publication Fee Transferred
Second Decision by Editor	2015-08-19 14:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-09-07 08:29
Articles in Press	2015-09-07 08:29
Edit the Manuscript by Language Editor	2015-09-14 23:57
Typeset the Manuscript	2015-09-24 11:47
Publish the Manuscript Online	2015-10-19 16:02

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Immunology
Manuscript Type	Review
Article Title	Programmed death-1/programmed death-L1 signaling pathway and its blockade in hepatitis C virus immunotherapy
Manuscript Source	Invited Manuscript
All Author List	Mohamed L Salem and Ahmed El-Badawy
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Development Fund (STDF) 5245 Science and Technology Development Fund (STDF) 1469 Tanta University Fund, Egypt Mohamed L Salem
Corresponding Author	Mohamed L Salem, PhD, Professor, Center of Excellence in Cancer Research, Tanta University, Tanta 31527, Egypt. cecr@unv.tanta.edu.eg
Key Words	hepatitis C virus; Programmed death-1; hepatitis C virus immunotherapy; Exhausted T cells; hepatitis C virus immune escape
Core Tip	The programmed death-1 (PD-1)/PD-L1 pathway is an attractive target for anti-hepatitis C virus (HCV) immunotherapy because it restores the functional capacities of HCV-specific T cells. This is an extremely promising development in anti-HCV vaccines research since restoration of exhausted anti-HCV T cells is a major challenge when developing either prophylactic or therapeutic vaccines. This review will discuss the correlation between PD-1 expression and the clinical outcome in HCV patients and how this information can be potentially applied to block PD-1/PD-L1 pathway for HCV immunotherapy.
Publish Date	2015-10-19 16:02
Citation	Salem ML, El-Badawy A. Programmed death-1/programmed death-L1 signaling pathway and its blockade in hepatitis C virus immunotherapy. World J Hepatol 2015; 7(23): 2449-2458
URL	http://www.wjgnet.com/1948-5182/full/v7/i23/2449.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i23.2449

Full Article (PDF)	WJH-7-2449.pdf
Full Article (Word)	WJH-7-2449.doc
Manuscript File	18215-Review.doc
Answering Reviewers	18215-Answering reviewers.pdf
Audio Core Tip	18215-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18215-Conflict-of-interest statement.pdf
Copyright License Agreement	18215-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	18215-Language certificate.pdf
Peer-review Report	18215-Peer-review(s).pdf
Scientific Misconduct Check	18215-Scientific misconduct check.pdf
Scientific Editor Work List	18215-Scientific editor work list.pdf