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11/19/2015 10:45:00 AM | Browse: 549 | Download: 1414
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Received |
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2015-04-15 18:06 |
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Peer-Review Started |
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2015-04-18 18:25 |
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2015-06-18 15:17 |
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Return for Revision |
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2015-06-20 19:03 |
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Revised |
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2015-07-11 01:44 |
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Second Decision |
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2015-09-28 14:29 |
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Accepted by Journal Editor-in-Chief |
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2015-09-29 10:43 |
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Accepted by Executive Editor-in-Chief |
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2015-10-13 17:06 |
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Articles in Press |
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2015-10-13 17:06 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-10-15 13:52 |
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Publish the Manuscript Online |
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2015-11-12 18:51 |
| ISSN |
2150-5349 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Research & Experimental Medicine |
| Manuscript Type |
Editorial |
| Article Title |
Role of peroxisome proliferator-activated receptors alpha and gamma in gastric ulcer: An overview of experimental evidences
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Lekha Saha |
| Funding Agency and Grant Number |
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| Corresponding Author |
Lekha Saha, Associate Professor, Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India. lekhasaha@rediffmail.com |
| Key Words |
Peroxisome proliferator-activated receptors; Gastric ulcer; Evidences |
| Core Tip |
Peroxisome proliferator-activated receptors (PPARs) are a nuclear hormone receptor family and act as transcription factors. PPARs are of three subtype’s, i.e., PPARα, PPARβ/δ, and PPARγ. The common sites where PPARα is expressed are muscle, heart, liver, small intestine and kidney. PPARγ is involved in modulation of various functions like inflammation, cell proliferation, and differentiation and it is commonly expressed in white blood cells (e.g., macrophages and monocytes) which are involved in immune activity and in the colon. Studies in animals have demonstrated the gastric antisecretory activity of PPAR-α agonists like ciprofibrate, bezafibrate and clofibrate. The majority of the experimental studies regarding the role of PPARγ activators is on pioglitazone and rosiglitazone. In all the studies, both the PPARγ activators showed protection against the gastric ulcer and also accelerate the ulcer healing in gastric ulcer model in rats. Therefore, PPARα and PPARγ can be explored as a target of gastric ulcer treatment. The aim of the present paper is to discuss the experimental evidences of the role of PPARs in gastric ulcer. |
| Publish Date |
2015-11-12 18:51 |
| Citation |
Saha L. Role of peroxisome proliferator-activated receptors alpha and gamma in gastric ulcer: An overview of experimental evidences. World J Gastrointest Pharmacol Ther 2015; 6(4): 120-126 |
| URL |
http://www.wjgnet.com/2150-5349/full/v6/i4/120.htm |
| DOI |
http://dx.doi.org/10.4292/wjgpt.v6.i4.120 |
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