BPG is committed to discovery and dissemination of knowledge
Featured Articles
11/19/2015 10:45:00 AM | Browse: 614 | Download: 2722
 |
Received |
|
2015-04-21 09:45 |
|
Peer-Review Started |
|
2015-04-21 11:37 |
 |
First Decision by Editorial Office Director |
|
|
|
Return for Revision |
|
2015-07-01 10:13 |
|
Revised |
|
2015-07-16 03:27 |
|
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2015-08-07 17:49 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2015-08-14 16:24 |
|
Articles in Press |
|
2015-08-14 16:25 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2015-10-16 13:58 |
|
Publish the Manuscript Online |
|
2015-11-12 18:51 |
| ISSN |
2150-5349 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Kunwar Shailubhai, Vaseem Palejwala, Krishna Priya Arjunan, Sayali Saykhedkar, Bradley Nefsky, John A Foss, Stephen Comiskey, Gary S Jacob and Scott E Plevy |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Kunwar Shailubhai, Doctor of Philosophy, Chief Scientific Officer, R and D Center, Synergy Pharmaceuticals Inc., 3805 Old Easton Road, Doylestown, PA 18902, United States. shailu@synergypharma.com |
| Key Words |
Guanylate cyclase-C; Uroguanylin; Plecanatide; Dolcanatide; Inflammatory bowel disease |
| Core Tip |
Plecanatide (SP-304) and dolcanatide (SP-333) are structurally close analogs of the human endogenous natriuretic peptide uroguanylin, a ligand of guanylate cyclase-C (GC-C). Here we report that oral treatment with plecanatide or dolcanatide effectively ameliorates colitis in acute and chronic models of murine experimental colitis. The anti-inflammatory activity of plecanatide and dolcanatide was comparable to that achieved after treatment with sulfasalazine or 5-amino salicylic acid. This is the first-ever study reporting the therapeutic utility of GC-C agonists as a new class of orally delivered and mucosally active drug candidates for the treatment and management of inflammatory bowel diseases in humans. |
| Publish Date |
2015-11-12 18:51 |
| Citation |
Shailubhai K, Palejwala V, Arjunan KP, Saykhedkar S, Nefsky B, Foss JA, Comiskey S, Jacob GS, Plevy SE. Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis. World J Gastrointest Pharmacol Ther 2015; 6(4): 213-222 |
| URL |
http://www.wjgnet.com/2150-5349/full/v6/i4/213.htm |
| DOI |
http://dx.doi.org/10.4292/wjgpt.v6.i4.213 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
