Publication Name	World Journal of Cardiology
Manuscript ID	18463
Country

Received	2015-04-21 08:30
Peer-Review Started	2015-04-21 14:30
To Make the First Decision	2015-05-13 19:28
Return for Revision	2015-05-19 11:38
Revised	2015-05-22 00:38
Second Decision	2015-07-02 09:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-07-14 09:58
Articles in Press	2015-07-14 09:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-09 20:57
Publish the Manuscript Online	2015-09-20 21:45

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Adrenal G protein-coupled receptor kinase-2 in regulation of sympathetic nervous system activity in heart failure
Manuscript Source	Invited Manuscript
All Author List	Katie A McCrink, Ava Brill and Anastasios Lymperopoulos
Funding Agency and Grant Number
Corresponding Author	Anastasios Lymperopoulos, PhD, FAHA, Associate Professor of Pharmacology, Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences, Nova Southeastern University College of Pharmacy, 3200 S. University Dr., HPD (Terry) Bldg/Room 1338, Ft. Lauderdale, FL 33328-2018, United States. al806@nova.edu
Key Words	G protein-coupled receptor; G protein-coupled receptor kinase; Heart failure; Sympathetic nervous system; Adrenergic receptor; Adrenal medulla
Core Tip	The present manuscript is a mini-review describing the current knowledge in the field of adrenal GRKs and βarrestins, both of which are protein families that regulate adrenergic receptor function throughout the cardiovascular system. We specifically discuss the roles of these proteins in the adrenal medulla, as they pertain to regulation of catecholamine secretion and of sympathetic activity in chronic heart failure (HF). We also outline the exciting new possibilities of targeting these molecules in the adrenal glands for HF therapy.
Publish Date	2015-09-20 21:45
Citation	McCrink KA, Brill A, Lymperopoulos A. Adrenal G protein-coupled receptor kinase-2 in regulation of sympathetic nervous system activity in heart failure. World J Cardiol 2015; 7(9): 539-543
URL	http://www.wjgnet.com/1949-8462/full/v7/i9/539.htm
DOI	http://dx.doi.org/10.4330/wjc.v7.i9.539

Full Article (PDF)	WJC-7-539.pdf
Full Article (Word)	WJC-7-539.doc
Manuscript File	18463-Review.docx
Answering Reviewers	18463-Answering reviewers.pdf
Audio Core Tip	18463-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	18463-Conflict-of-interest statement.pdf
Copyright License Agreement	18463-Copyright assignment.pdf
Peer-review Report	18463-Peer-review(s).pdf
Scientific Misconduct Check	18463-Scientific misconduct check.pdf
Scientific Editor Work List	18463-Scientific editor work list.pdf