Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	19647
Country	Spain

Received	2015-05-15 08:42
Peer-Review Started	2015-05-20 10:35
To Make the First Decision	2015-07-06 14:45
Return for Revision	2015-07-10 10:21
Revised	2015-07-15 16:46
Second Decision	2015-07-21 19:39
Accepted by Journal Editor-in-Chief	2015-07-24 14:18
Accepted by Executive Editor-in-Chief	2015-08-11 15:18
Articles in Press	2015-08-11 15:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-09 15:11
Publish the Manuscript Online	2015-09-29 10:43

ISSN	1948-9366 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Surgery
Manuscript Type	Basic Study
Article Title	Response to chemoradiotherapy and lymph node involvement in locally advanced rectal cancer
Manuscript Source	Invited Manuscript
All Author List	Luis J García-Flórez, Guillermo Gómez-Álvarez, Ana M Frunza, Luis Barneo-Serra and Manuel F Fresno-Forcelledo
Funding Agency and Grant Number
Corresponding Author	Luis J García-Flórez, MD, PhD, Asso­ciate Professor of Surgery, General and Digestive Surgery Service, Hospital San Agustín, Camino de Heros s/n, 33401 Avilés, Spain. luisjgf@gmail.com
Key Words	Response to treatment; Neoadjuvant therapy; Rectal cancer; Chemoradiotherapy; Lymph node involvement
Core Tip	The treatment of rectal cancer has evolved significantly in recent decades. The response of the primary tumor to neoadjuvant therapy, measured by tumor regression grading, seems to be a good prognostic factor, although this relationship is controversial. One of the most important prognostic factors is lymph node stage, but its relationship with the response to neoadyuvant therapy has not been studied extensively. In our series the response is correlated with lymph node involvement in the surgical specimens. Tumor regression grading score could therefore have clinical implications in the future in order to provide tailored therapies.
Publish Date	2015-09-29 10:43
Citation	García-Flórez LJ, Gómez-Álvarez G, Frunza AM, Barneo-Serra L, Fresno-Forcelledo MF. Response to chemoradiotherapy and lymph node involvement in locally advanced rectal cancer. World J Gastrointest Surg 2015; 7(9): 196-202
URL	http://www.wjgnet.com/1948-9366/full/v7/i9/196.htm
DOI	http://dx.doi.org/10.4240/wjgs.v7.i9.196

Full Article (PDF)	WJGS-7-196.pdf
Full Article (Word)	WJGS-7-196.doc
Manuscript File	19647-Review.docx
Answering Reviewers	19647-Answering reviewers.pdf
Audio Core Tip	19647-Audio core tip.m4a
Biostatistics Review Certificate	19647-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	19647-Conflict-of-interest statement.pdf
Copyright License Agreement	19647-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	19647-Institutional review board statement.pdf
Peer-review Report	19647-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	19647-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	19647-Scientific misconduct check.pdf
Scientific Editor Work List	19647-Scientific editor work list.pdf