BPG is committed to discovery and dissemination of knowledge
Featured Articles
4/7/2016 9:48:00 AM | Browse: 1098 | Download: 2412
Publication Name World Journal of Immunology
Manuscript ID 19718
Country/Territory United Kingdom
Received
2015-05-18 15:19
Peer-Review Started
2015-05-20 08:36
To Make the First Decision
2015-10-08 15:54
Return for Revision
2015-10-17 18:26
Revised
2015-10-30 08:32
Second Decision
2016-01-25 14:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-02-16 09:02
Articles in Press
2016-02-16 09:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-03-24 17:55
Publish the Manuscript Online
2016-03-28 08:57
ISSN 2219-2824 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Immunology
Manuscript Type Basic Study
Article Title Intracellular localisation of Mycobacterium marinum in mast cells
Manuscript Source Invited Manuscript
All Author List Sadiyo Siad, Simon Byrne, Galina Mukamolova and Cordula Stover
Funding Agency and Grant Number
Funding Agency Grant Number
Faculty for the Future Fellowship grant by the Schlumberger Foundation (to Siad S)
Corresponding Author Dr. med. Cordula Stover, PhD, Senior Lecturer in Immunology, Department of Infection, Immunity and Inflammation, College of Medicine, Biological Sciences and Psychology, University of Leicester, University Road, Leicester LE1 9HN, United Kingdom. cms13@le.ac.uk
Key Words Mast cells; Mycobacterium marinum; Microscopy; Infection; Degranulation
Core Tip Mycobacterium marinum (M. marinum) is easily culturable and shows promise as a model to understand in mammalian cells the pathogenicity of M. tuberculosis. We used M. marinum to study uptake and elimination of M. marinum by mast cells, being abundant immune effector cells. A range of imaging techniques was used to unequivocally show the intracellular presence of M. marinum. Mast cells did not control the replication of M. marinum but reacted in a pro-inflammatory way. This is consistent with mast cells being orchestrators of inflammation. In summary, we clearly show that M. marinum can infect mast cells, survive and replicate within.
Publish Date 2016-03-28 08:57
Citation Siad S, Byrne S, Mukamolova G, Stover C. Intracellular localisation of Mycobacterium marinum in mast cells. World J Immunol 2016; 6(1): 83-95
URL http://www.wjgnet.com/2219-2824/full/v6/i1/83.htm
DOI http://dx.doi.org/10.5411/wji.v6.i1.83
Full Article (PDF) WJI-6-83.pdf
Full Article (Word) WJI-6-83.doc
Manuscript File 19718-Review.docx
Answering Reviewers 19718-Answering reviewers.pdf
Audio Core Tip 19718-Audio core tip.mp3
Biostatistics Review Certificate 19718-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 19718-Conflict-of-interest statement.pdf
Copyright License Agreement 19718-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 19718-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 19718-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 19718-Institutional review board statement.pdf
Peer-review Report 19718-Peer-review(s).pdf
Scientific Misconduct Check 19718-Scientific misconduct check.pdf
Scientific Editor Work List 19718-Scientific editor work list.pdf