Publication Name	World Journal of Pharmacology
Manuscript ID	20186
Country	Canada

Received	2015-05-29 20:21
Peer-Review Started	2015-06-01 10:55
To Make the First Decision	2015-07-27 15:50
Return for Revision	2015-08-04 11:39
Revised	2015-09-10 04:54
Second Decision	2015-10-08 12:21
Accepted by Journal Editor-in-Chief	2015-10-08 18:44
Accepted by Company Editor-in-Chief	2015-10-19 15:27
Articles in Press	2015-10-19 15:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-04 10:03
Publish the Manuscript Online	2015-12-08 16:45

ISSN	2220-3192 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Rheumatology
Manuscript Type	Review
Article Title	Role of mitogen- and stress-activated kinases in inflammatory arthritis
Manuscript Source	Invited Manuscript
All Author List	Sylvain G Bourgoin and Weili Hui
Funding Agency and Grant Number	Funding Agency Grant Number Arthritis Society of Canada RG10/011(to Bourgoin SG)
Corresponding Author	Sylvain G Bourgoin, PhD, Division of Infectious Disease and Immunity, CHU de Québec Research Center and Department of Microbiology-Infectious Disease and Immunology, Faculty of Medicine, Laval University, 2705 Boul Laurier, Québec G1V 4G2, Canada. sylvain.bourgoin@crchudequebec.ulaval.ca
Key Words	Lysophosphatidic acid; Mitogen activated protein kinase; Chemokines; Cytokines; Mitogen- and stress-activated kinases; Inflammation; cAMP response element-binding protein; Arthritis
Core Tip	Extracellular signal-regulated kinases 1/2 and p38 mitogen activated protein kinase cascades are activated in response to stimulation with inflammatory stimuli, including lysophosphatidic acid, and are able to activate mitogen- and stress-activated kinase (MSK) 1 and MSK2 in human synovial fibroblasts. MSKs then phosphorylate the transcription factor cAMP response element-binding protein (CREB), leading to the production of pro-inflammatory and anti-inflammatory cytokines. In addition to CREB, many other downstream effectors of MSK1/2 such as nuclear factor-kappa B, histone H3, the E3 ubiquitin ligase, Tripartite motif containing 7 and high mobility group nucleosome binding domain 1 have been reported and suggested to play important functions in immunity and disease states, including arthritis.
Publish Date	2015-12-08 16:45
Citation	Bourgoin SG, Hui W. Role of mitogen- and stress-activated kinases in inflammatory arthritis. World J Pharmacol 2015; 4(4): 265-273
URL	http://www.wjgnet.com/2220-3192/full/v4/i4/265.htm
DOI	http://dx.doi.org/10.5497/wjp.v4.i4.265

Full Article (PDF)	WJP-4-265.pdf
Full Article (Word)	WJP-4-265.doc
Manuscript File	20186-Review.docx
Answering Reviewers	20186-Answering reviewers.pdf
Audio Core Tip	20186-Audio core tip.wav
Conflict-of-Interest Disclosure Form	20186-Conflict-of-interest statement.pdf
Copyright License Agreement	20186-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20186-Language certificate.pdf
Peer-review Report	20186-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20186-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20186-Scientific misconduct check.pdf
Scientific Editor Work List	20186-Scientific editor work list.pdf