Publication Name	World Journal of Hepatology
Manuscript ID	20793
Country	Italy

Received	2015-06-22 11:19
Peer-Review Started	2015-06-22 15:55
To Make the First Decision	2015-08-16 17:27
Return for Revision	2015-08-25 19:48
Revised	2015-08-26 08:29
Second Decision	2015-10-13 08:42
Accepted by Journal Editor-in-Chief	2015-10-13 22:23
Accepted by Executive Editor-in-Chief	2015-10-27 18:20
Articles in Press	2015-10-27 18:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-12 11:08
Publish the Manuscript Online	2015-11-18 11:12

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Challenges of liver cancer: Future emerging tools in imaging and urinary biomarkers
Manuscript Source	Invited Manuscript
All Author List	Francesca M Trovato, Joshua M Tognarelli, Mary ME Crossey, Daniela Catalano, Simon D Taylor-Robinson and Guglielmo M Trovato
Funding Agency and Grant Number
Corresponding Author	Guglielmo M Trovato, MD, Dipartimento di Medicina Clinica e Sperimentale, Scuola di Medicina, Università di Catania, Via Santa Sofia 78, 95100 Catania, Italy. guglielmotrovato@unict.it
Key Words	Virus hepatitis; Liver cancer; Ultrasound; Fibrosis; Urinary biomarkers
Core Tip	There is an increasing need for non-invasive assessment of liver disease. New techniques to assess liver damage from transient elastography to experimental techniques, such as in vitro urinary nuclear magnetic resonance spectroscopy are currently investigated. The guidelines of sustainability in countries with limited resources, facilities and low financial income can be seen as an opportunity for addressing research toward low-cost diagnostics and for driving clinical practice toward more streamlined technology, with ultimate benefits for the populations of poorer countries around the world. In this perspective, urinary biomarkers of liver cancer and ultrasound imaging are two complementary models.
Publish Date	2015-11-18 11:12
Citation	Trovato FM, Tognarelli JM, Crossey MME, Catalano D, Taylor-Robinson SD, Trovato GM. Challenges of liver cancer: Future emerging tools in imaging and urinary biomarkers. World J Hepatol 2015; 7(26): 2664-2675
URL	http://www.wjgnet.com/1948-5182/full/v7/i26/2664.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i26.2664

Full Article (PDF)	WJH-7-2664.pdf
Full Article (Word)	WJH-7-2664.doc
Manuscript File	20793-Review.docx
Answering Reviewers	20793-Answering reviewers.pdf
Audio Core Tip	20793-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20793-Conflict-of-interest statement.pdf
Copyright License Agreement	20793-Copyright assignment.pdf
Peer-review Report	20793-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20793-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20793-Scientific misconduct check.pdf
Scientific Editor Work List	20793-Scientific editor work list.pdf