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12/17/2015 6:44:00 PM | Browse: 641 | Download: 2797
Publication Name World Journal of Translational Medicine
Manuscript ID 20826
Country/Territory Japan
Received
2015-06-24 10:28
Peer-Review Started
2015-06-29 12:09
To Make the First Decision
2015-08-16 17:29
Return for Revision
2015-08-25 20:07
Revised
2015-09-08 11:07
Second Decision
2015-11-02 14:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-11-11 17:58
Articles in Press
2015-11-11 17:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-12-10 09:46
Publish the Manuscript Online
2015-12-15 17:37
ISSN 2220-6132 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Transplantation
Manuscript Type Basic Study
Article Title Pro- vs anti-stenotic capacities of type-I vs type-II human induced pluripotent-derived endothelial cells
Manuscript Source Invited Manuscript
All Author List Miwako Nishio, Masako Nakahara, Koichi Saeki, Katsuhito Fujiu, Hiroshi Iwata, Ichiro Manabe, Akira Yuo and Kumiko Saeki
Funding Agency and Grant Number
Funding Agency Grant Number
Ministry of Health, Labour and Welfare of Japan KHD1017
JST, PRESTO
Corresponding Author Kumiko Saeki, MD, PhD, Division Chief, Department of Disease Control, Research Institute, National Center for Global Health and Medicine, 1-21-1 Toyama Shinjukuiku, Tokyo 162-8655, Japan. saeki@ri.ncgm.go.jp
Key Words Vascular endothelial cells; Vasa vasorum; Arteriostenosis; Wire injury; Human induced pluripotent stem cells
Core Tip We previously reported that human vascular endothelial cells (VECs) were classified into two categories by their in vitro effects on the proliferation of vascular smooth muscle cells: Pro-proliferative VECs (type-I) and anti-proliferative VECs (type-II). Applying our new technique to transplant human VECs onto the luminal surface of endothelial layer-removed murine arteries, the in vivo relevance of the concept for VEC categorization was validated. Transplantation of pro-proliferative VECs (type-I) resulted in total stenosis while that of anti-proliferative VECs (type-II) completely blocked the development of arteriostenosis. Thus, pro-stenosis (type-I) and anti-stenotic (type-II) capacities were verified in vivo.
Publish Date 2015-12-15 17:37
Citation Nishio M, Nakahara M, Saeki K, Fujiu K, Iwata H, Manabe I, Yuo A, Saeki K. Pro- vs anti-stenotic capacities of type-I vs type-II human induced pluripotent-derived endothelial cells. World J Transl Med 2015; 4(3): 113-122
URL http://www.wjgnet.com/2220-6132/full/v4/i3/113.htm
DOI http://dx.doi.org/10.5528/wjtm.v4.i3.113
Full Article (PDF) WJTM-4-113.pdf
Full Article (Word) WJTM-4-113.doc
Manuscript File 20826-Review.docx
Answering Reviewers 20826-Answering reviewers.pdf
Audio Core Tip 20826-Audio core tip.wma
Biostatistics Review Certificate 20826-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 20826-Conflict-of-interest statement.pdf
Copyright License Agreement 20826-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 20826-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 20826-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 20826-Language certificate.pdf
Peer-review Report 20826-Peer-review(s).pdf
Scientific Misconduct Check 20826-Scientific misconduct check.pdf
Scientific Editor Work List 20826-Scientific editor work list.pdf