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12/25/2015 3:30:00 PM | Browse: 491 | Download: 1454
Publication Name World Journal of Meta-Analysis
Manuscript ID 20949
Country/Territory United Kingdom
Received
2015-06-27 10:23
Peer-Review Started
2015-06-28 09:11
To Make the First Decision
2015-09-17 12:24
Return for Revision
2015-09-18 09:17
Revised
2015-10-13 03:25
Second Decision
2015-11-02 14:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-12-04 16:12
Articles in Press
2015-12-04 16:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-12-16 08:31
Publish the Manuscript Online
2015-12-24 21:31
ISSN 2308-3840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, General & Internal
Manuscript Type Meta-Analysis
Article Title Risk of pancreatic adverse events associated with the use of glucagon-like peptide-1 receptor agonist and dipeptidyl peptidase-4 inhibitor drugs: A systematic review and meta-analysis of randomized trials
Manuscript Source Invited Manuscript
All Author List Hasan M Shihab, Tokunbo Akande, Kacie Armstrong, Sonal Singh and Yoon K Loke
Funding Agency and Grant Number
Corresponding Author Yoon K Loke, MD, Professor, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, United Kingdom. y.loke@uea.ac.uk
Key Words Diabetes mellitus; Pancreatitis; Glucagon-like peptide-1 agonists; Dipeptidyl peptidase-4 inhibitors; Meta-analysis
Core Tip There is conflicting data on the risk of pancreatitis with glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors. We performed a meta-analysis of 68 randomized controlled trials of 11 different GLP-1 or DPP-4 targeted drugs. The incidence of pancreatic adverse events in the trials was generally low and we did not find any definitive evidence for pancreatitis or pancreatic cancer amongst the trials. However, we found a significantly raised risk of elevated pancreatic enzymes in a small number of trials that reported such enzyme elevations.
Publish Date 2015-12-24 21:31
Citation Shihab HM, Akande T, Armstrong K, Singh S, Loke YK. Risk of pancreatic adverse events associated with the use of glucagon-like peptide-1 receptor agonist and dipeptidyl peptidase-4 inhibitor drugs: A systematic review and meta-analysis of randomized trials. World J Meta-Anal 2015; 3(6): 254-283
URL http://www.wjgnet.com/2308-3840/full/v3/i6/254.htm
DOI http://dx.doi.org/10.13105/wjma.v3.i6.254
Full Article (PDF) WJMA-3-254.pdf
Full Article (Word) WJMA-3-254.doc
Manuscript File 20949-Review.docx
Answering Reviewers 20949-Answering reviewers.pdf
Audio Core Tip 20949-Audio core tip.mp3
Biostatistics Review Certificate 20949-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 20949-Conflict-of-interest statement.pdf
Copyright License Agreement 20949-Copyright assignment.pdf
Supplementary Material Supplementary_Material_20150626183927.docx
Peer-review Report 20949-Peer-review(s).pdf
Scientific Misconduct Check 20949-Scientific misconduct check.pdf
Scientific Editor Work List 20949-Scientific editor work list.pdf