Publication Name	World Journal of Gastroenterology
Manuscript ID	21196
Country	Italy

Received	2015-06-30 15:51
Peer-Review Started	2015-07-04 15:44
To Make the First Decision	2015-07-20 13:44
Return for Revision	2015-07-28 11:36
Revised	2015-08-03 10:45
Second Decision	2015-09-23 19:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-30 09:04
Articles in Press	2015-09-30 09:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-21 17:27
Publish the Manuscript Online	2015-11-11 13:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Diagnostic and therapeutic management of hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Francesco Bellissimo, Marilia Rita Pinzone, Bruno Cacopardo and Giuseppe Nunnari
Funding Agency and Grant Number
Corresponding Author	Giuseppe Nunnari, MD, PhD, MPH, Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Catania, Via Palermo 636, 95100 Catania, Italy. gnunnari@hotmail.com
Key Words	Cancer; Chronic hepatitis; Cirrhosis; Hepatitis B virus; Hepatocellular carcinoma; Hepatitis C virus; Liver
Core Tip	Hepatocellular carcinoma is an increasing health problem, representing the second cause of cancer-related mortality worldwide. The major risk factor for hepatocellular carcinoma (HCC) is cirrhosis. Early diagnosis is crucial for curative treatments. As a consequence, patients at risk of developing HCC should undergo surveillance programs in order to detect HCC in the initial stage. Surgical resection, radiofrequency ablation and liver transplantation are considered the cornerstones of curative therapy, while for patients with more advanced HCC recommended options include sorafenib and trans-arterial chemo-embolization.
Publish Date	2015-11-11 13:34
Citation	Bellissimo F, Pinzone MR, Cacopardo B, Nunnari G. Diagnostic and therapeutic management of hepatocellular carcinoma. World J Gastroenterol 2015; 21(42): 12003-12021
URL	http://www.wjgnet.com/1007-9327/full/v21/i42/12003.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i42.12003

Full Article (PDF)	WJG-21-12003.pdf
Full Article (Word)	WJG-21-12003.doc
Manuscript File	21196-Review.docx
Answering Reviewers	21196-Answering reviewers.pdf
Audio Core Tip	21196-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21196-Conflict-of-interest statement.pdf
Copyright License Agreement	21196-Copyright assignment.pdf
Peer-review Report	21196-Peer-review(s).pdf
Scientific Misconduct Check	21196-Scientific misconduct check.pdf
Scientific Editor Work List	21196-Scientific editor work list.pdf