Publication Name	World Journal of Transplantation
Manuscript ID	21206
Country	France

Received	2015-06-30 17:27
Peer-Review Started	2015-07-05 23:47
First Decision by Editorial Office Director
Return for Revision	2015-07-31 14:23
Revised	2015-08-19 00:00
Publication Fee Transferred
Second Decision by Editor	2015-09-14 10:22
Second Decision by Editor-in-Chief	2015-09-17 17:48
Final Decision by Editorial Office Director	2015-09-30 18:26
Articles in Press	2015-09-30 18:26
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-15 11:23
Publish the Manuscript Online	2015-12-23 08:25

ISSN	2220-3230 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Transplantation
Manuscript Type	Review
Article Title	B cells with regulatory properties in transplantation tolerance
Manuscript Source	Invited Manuscript
All Author List	Justine Durand and Elise Chiffoleau
Funding Agency and Grant Number	Funding Agency Grant Number Fondation PROGREFFE to Justine Durand Societé Francophone de Transplantation to Justine Durand National Research Agency via the investment of the future program ANR-10-IBHU-005 Nantes Metropole and the Pays de la Loire Region
Corresponding Author	Elise Chiffoleau, PhD, INSERM U1064, Institut de Transplantation et de Recherche en Transplantation Urologie Nephrologie, ITUN, IHU, CHU Nantes, Université de Nantes, CHU Hotel-Dieu, 30 Bd Jean Monnet 44093 Nantes, F44000 Nantes, France. elise.chiffoleau@univ-nantes.fr
Key Words	Regulatory B cells; Suppression; Immuno-suppressive cytokines interleukin-10; Antibodies; Tolerance
Core Tip	Regulatory B cells have been characterized mainly in auto-immune diseases but emerging literature suggests their role in graft tolerance in transplantation. Regulatory B cells exhibit different phenotypes and act by multiple mechanisms such as secretion of immuno-suppressive cytokines, cytotoxicity, expression of inhibitory receptors or secretion of non-inflammatory antibodies. Better characterization of the development, phenotype and mode of action of these cells seems urgent to develop novel approaches to manipulate the different B cell subsets and the response to the graft in a clinical setting.
Publish Date	2015-12-23 08:25
Citation	Durand J, Chiffoleau E. B cells with regulatory properties in transplantation tolerance. World J Transplant 2015; 5(4): 196-208
URL	http://www.wjgnet.com/2220-3230/full/v5/i4/196.htm
DOI	http://dx.doi.org/10.5500/wjt.v5.i4.196

Full Article (PDF)	WJT-5-196.pdf
Full Article (Word)	WJT-5-196.doc
Manuscript File	21206-Review.docx
Answering Reviewers	21206-Answering reviewers.pdf
Audio Core Tip	21206-Audio core tip.wav
Conflict-of-Interest Disclosure Form	21206-Conflict-of-interest statement.pdf
Copyright License Agreement	21206-Copyright assignment.pdf
Peer-review Report	21206-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	21206-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	21206-Scientific misconduct check.pdf
Scientific Editor Work List	21206-Scientific editor work list.pdf