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5/20/2016 9:33:00 AM | Browse: 572 | Download: 1093
Publication Name World Journal of Gastrointestinal Pathophysiology
Manuscript ID 21743
Country/Territory Australia
Received
2015-07-28 14:04
Peer-Review Started
2015-07-30 08:35
To Make the First Decision
2015-09-28 13:35
Return for Revision
2015-10-10 14:02
Revised
2015-10-21 15:14
Second Decision
2016-02-22 11:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-03-09 12:32
Articles in Press
2016-03-09 12:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-04-19 14:05
Publish the Manuscript Online
2016-05-12 16:59
ISSN 2150-5330 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pathology
Manuscript Type Review
Article Title Differential role of Hedgehog signaling in human pancreatic (patho-) physiology: An up to date review
Manuscript Source Invited Manuscript
All Author List Eckhard Klieser, Stefan Swierczynski, Christian Mayr, Tarkan Jäger, Johanna Schmidt, Daniel Neureiter, Tobias Kiesslich and Romana Illig
Funding Agency and Grant Number
Corresponding Author Daniel Neureiter, MA, Associate Professor, Institute of Pathology, Paracelsus Medical University, Salzburger Landeskliniken (SALK), Müllner Haupstrasse 48, 5020 Salzburg, Austria. d.neureiter@salk.at
Key Words Pancreatic cancer; Hedgehog; Pancreatitis; Pancreas; Development
Core Tip The Hedgehog (Hh) pathway is a ligand-dependent and evolutionary conserved cellular signaling mechanism with various physiologic (development) and pathogenetic functions (especially carcinogenesis). Concerted Hh signaling is essential for human pancreatic development and homeostasis of the gastrointestinal tract. Aberrant expression within the Hh signaling pathway results in malformations like annular pancreas. The Janus aspect of Hh in pancreatitis is reflected by the protective role of Hh in acute pancreatitis vs the disease-progressive function of Hh in chronic pancreatitis (CP), whereby CP is linked to pancreatic cancerogenesis via pancreatic intraepithelial neoplasia (PanIn). Starting with PanIn and ending up at metastatic disease, Hh pathway is expressed in ductal pancreatic cancer thereby influencing and being paracrine influenced by the tumor microenvironment.
Publish Date 2016-05-12 16:59
Citation Klieser E, Swierczynski S, Mayr C, Jäger T, Schmidt J, Neureiter D, Kiesslich T, Illig R. Differential role of Hedgehog signaling in human pancreatic (patho-) physiology: An up to date review. World J Gastrointest Pathophysiol 2016; 7(2): 199-210
URL http://www.wjgnet.com/2150-5330/full/v7/i2/199.htm
DOI http://dx.doi.org/10.4291/wjgp.v7.i2.199
Full Article (PDF) WJGP-7-199.pdf
Full Article (Word) WJGP-7-199.doc
Manuscript File 21743-Review.doc
Answering Reviewers 21743-Answering reviewers.pdf
Audio Core Tip 21743-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 21743-Conflict-of-interest statement.pdf
Copyright License Agreement 21743-Copyright assignment.pdf
Peer-review Report 21743-Peer-review(s).pdf
Scientific Misconduct Check 21743-Scientific misconduct check.pdf
Scientific Editor Work List 21743-Scientific editor work list.pdf