Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	21743
Country	Australia

Received	2015-07-28 14:04
Peer-Review Started	2015-07-30 08:35
To Make the First Decision	2015-09-28 13:35
Return for Revision	2015-10-10 14:02
Revised	2015-10-21 15:14
Second Decision	2016-02-22 11:27
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-03-09 12:32
Articles in Press	2016-03-09 12:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-04-19 14:05
Publish the Manuscript Online	2016-05-12 16:59

ISSN	2150-5330 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Pathology
Manuscript Type	Review
Article Title	Differential role of Hedgehog signaling in human pancreatic (patho-) physiology: An up to date review
Manuscript Source	Invited Manuscript
All Author List	Eckhard Klieser, Stefan Swierczynski, Christian Mayr, Tarkan Jäger, Johanna Schmidt, Daniel Neureiter, Tobias Kiesslich and Romana Illig
Funding Agency and Grant Number
Corresponding Author	Daniel Neureiter, MA, Associate Professor, Institute of Pathology, Paracelsus Medical University, Salzburger Landeskliniken (SALK), Müllner Haupstrasse 48, 5020 Salzburg, Austria. d.neureiter@salk.at
Key Words	Pancreatic cancer; Hedgehog; Pancreatitis; Pancreas; Development
Core Tip	The Hedgehog (Hh) pathway is a ligand-dependent and evolutionary conserved cellular signaling mechanism with various physiologic (development) and pathogenetic functions (especially carcinogenesis). Concerted Hh signaling is essential for human pancreatic development and homeostasis of the gastrointestinal tract. Aberrant expression within the Hh signaling pathway results in malformations like annular pancreas. The Janus aspect of Hh in pancreatitis is reflected by the protective role of Hh in acute pancreatitis vs the disease-progressive function of Hh in chronic pancreatitis (CP), whereby CP is linked to pancreatic cancerogenesis via pancreatic intraepithelial neoplasia (PanIn). Starting with PanIn and ending up at metastatic disease, Hh pathway is expressed in ductal pancreatic cancer thereby influencing and being paracrine influenced by the tumor microenvironment.
Publish Date	2016-05-12 16:59
Citation	Klieser E, Swierczynski S, Mayr C, Jäger T, Schmidt J, Neureiter D, Kiesslich T, Illig R. Differential role of Hedgehog signaling in human pancreatic (patho-) physiology: An up to date review. World J Gastrointest Pathophysiol 2016; 7(2): 199-210
URL	http://www.wjgnet.com/2150-5330/full/v7/i2/199.htm
DOI	http://dx.doi.org/10.4291/wjgp.v7.i2.199

Full Article (PDF)	WJGP-7-199.pdf
Full Article (Word)	WJGP-7-199.doc
Manuscript File	21743-Review.doc
Answering Reviewers	21743-Answering reviewers.pdf
Audio Core Tip	21743-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21743-Conflict-of-interest statement.pdf
Copyright License Agreement	21743-Copyright assignment.pdf
Peer-review Report	21743-Peer-review(s).pdf
Scientific Misconduct Check	21743-Scientific misconduct check.pdf
Scientific Editor Work List	21743-Scientific editor work list.pdf