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1/29/2016 3:09:00 PM | Browse: 561 | Download: 1316
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Received |
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2015-08-08 12:58 |
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Peer-Review Started |
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2015-08-11 10:20 |
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To Make the First Decision |
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2015-09-16 13:56 |
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Return for Revision |
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2015-09-18 18:00 |
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Revised |
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2015-10-13 05:36 |
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Second Decision |
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2015-11-30 09:42 |
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Accepted by Journal Editor-in-Chief |
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2015-11-30 09:54 |
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Accepted by Executive Editor-in-Chief |
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2015-12-11 16:39 |
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Articles in Press |
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2015-12-11 16:40 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-01-20 14:22 |
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Publish the Manuscript Online |
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2016-01-29 11:06 |
| ISSN |
2150-5349 (online) |
| Open Access |
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Recent discoveries and emerging therapeutics in eosinophilic esophagitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Aakash Goyal and Edaire Cheng |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institutes of Health |
K08-DK099383 (to Cheng E) |
| NASPGHAN Foundation/AstraZeneca Award |
to Cheng E |
| AGA Research Scholar Award |
to Cheng E |
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| Corresponding Author |
Edaire Cheng, MD, Assistant Professor, Department of Pediatrics and Internal Medicine, Division of Gastroenterology, Children’s Health Children’s Medical Center and University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9063,
United States. edaire.cheng@utsouthwestern.edu
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| Key Words |
Eosinophilic esophagitis; Interleukin-5; Proton pump inhibitors; Proton pump inhibitor-responsive esophageal eosinophilia; Gastroesophageal reflux disease; Eotaxin-3 |
| Core Tip |
In this review, we will discuss recent challenges and discoveries in eosinophilic esophagitis (EoE). While current treatment options are limited, mainly dietary therapy and steroids, we will highlight emerging therapeutics targeting pathogenic mechanisms of the disease. Although EoE is an allergy-mediated disease, the overlapping features of EoE and gastroesophageal reflux disease (GERD) present a diagnostic quandary in distinguishing the two disorders. EoE and GERD are not mutually exclusive and might share a complex relationship. We will review how proton pump inhibitor (PPI)s might exert therapeutic effects in EoE, and why a PPI response does not provide clear diagnostic distinction between EoE and GERD.
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| Publish Date |
2016-01-29 11:06 |
| Citation |
Goyal A, Cheng E. Recent discoveries and emerging therapeutics in eosinophilic esophagitis. World J Gastrointest Pharmacol Ther 2016; 7(1): 21-32 |
| URL |
http://www.wjgnet.com/2150-5349/full/v7/i1/21.htm |
| DOI |
http://dx.doi.org/10.4292/wjgpt.v7.i1.21 |
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