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12/23/2015 5:31:00 PM | Browse: 539 | Download: 1411
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Received |
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2015-08-12 08:12 |
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Peer-Review Started |
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2015-08-13 08:50 |
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To Make the First Decision |
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2015-09-17 13:35 |
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Return for Revision |
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2015-09-19 15:06 |
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Revised |
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2015-10-04 04:14 |
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Second Decision |
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2015-11-12 14:02 |
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Accepted by Journal Editor-in-Chief |
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2015-11-13 22:04 |
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Accepted by Executive Editor-in-Chief |
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2015-11-25 15:39 |
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Articles in Press |
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2015-11-25 15:39 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-12-16 20:24 |
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Publish the Manuscript Online |
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2015-12-23 08:25 |
| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Minireviews |
| Article Title |
Role for urinary biomarkers in diagnosis of acute rejection in the transplanted kidney
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Basma Merhi, George Bayliss and Reginald Y Gohh |
| Funding Agency and Grant Number |
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| Corresponding Author |
Reginald Y Gohh, MD, Department of Medicine, Division of Kidney Transplantation, Rhode Island Hospital, APC 10, 593 Eddy St., Providence, RI 02903,
United States. rgohh@lifespan.org |
| Key Words |
Urinary biomarkers; Acute renal allograft rejection; Serum creatinine; Graft outcome; Urinary perforin; granzyme B and Fas-ligand mRNA; Urinary CXCL9 and CXCL10; Urinary FOXP3 mRNA; Urinary miRNA |
| Core Tip |
Through its urine output, the transplanted kidney can provide a window into the cellular and molecular events occurring within the graft, and potentially offers a noninvasive means of assessing kidney allograft status. An assay consisting of bio-markers of allograft injury using only urine samples from transplant recipients could provide many advan-tages over the current strategy of relying on changes in the serum creatinine and kidney biopsies. A rising creatinine is a nonspecific marker of graft dysfunction and a relative late marker of intragraft pathology, whereas kidney biopsies are inherently invasive. The role of non-invasive monitoring through plasma or urine biomarkers has been a topic of interest to the transplant community for many years and has been the subject of numerous publications. Our objective is to critically review the current literature to better delineate the role of these urinary biomarkers in predicting the risk of acute allograft rejection in kidney transplant recipients. |
| Publish Date |
2015-12-23 08:25 |
| Citation |
Merhi B, Bayliss G, Gohh RY. Role for urinary biomarkers in diagnosis of acute rejection in the transplanted kidney. World J Transplant 2015; 5(4): 251-260 |
| URL |
http://www.wjgnet.com/2220-3230/full/v5/i4/251.htm |
| DOI |
http://dx.doi.org/10.5500/wjt.v5.i4.251 |
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