Publication Name	World Journal of Nephrology
Manuscript ID	22424
Country	Germany

Received	2015-08-28 17:19
Peer-Review Started	2015-09-02 08:52
To Make the First Decision	2015-11-24 14:45
Return for Revision	2015-11-27 17:07
Revised	2015-12-07 18:59
Second Decision	2015-12-24 17:49
Accepted by Journal Editor-in-Chief	2015-12-27 20:35
Accepted by Executive Editor-in-Chief	2016-01-11 15:37
Articles in Press	2016-01-11 15:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-18 09:41
Publish the Manuscript Online	2016-03-01 14:46

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Immunology
Manuscript Type	Review
Article Title	Extracellular vesicles as mediators of vascular inflammation in kidney disease
Manuscript Source	Invited Manuscript
All Author List	Alexandra Helmke and Sibylle von Vietinghoff
Funding Agency and Grant Number
Corresponding Author	Dr. med. Sibylle von Vietinghoff, Division of Nephrology and Hypertension, Hannover Medical School, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany. vonvietinghoff.sibylle@mh-hannover.de
Key Words	Extracellular vesicle; Atherosclerosis; Kidney disease; Glomerulonephritis; Macrophage
Core Tip	This review addresses the role of extracellular vesicles (EVs) in vascular inflammation that can cause renal damage and is also shaped by uremic mediators. Vasculitides are common causes of renal damage. Functionally, neutrophil EVs induced by anti-neutrophil cytoplasmic antibody contribute to endothelial damage. EVs are main distributors of shiga toxin in the circulation and into tissues in typical hemolytic uremic syndrome. In atherosclerosis in patients with and without kidney disease, endothelial EVs are elevated. Uremic EVs are deficient in mediating vascular relaxation. EVs modulate mononuclear phagocyte differentiation, cytokine production, lipid phagocytosis and antigen presentation, atherosclerotic inflammatory processes significantly altered in uremia.
Publish Date	2016-03-01 14:46
Citation	Helmke A, von Vietinghoff S. Extracellular vesicles as mediators of vascular inflammation in kidney disease. World J Nephrol 2016; 5(2): 125-138
URL	http://www.wjgnet.com/2220-6124/full/v5/i2/125.htm
DOI	http://dx.doi.org/10.5527/wjn.v5.i2.125

Full Article (PDF)	WJN-5-125.pdf
Full Article (Word)	WJN-5-125.doc
Manuscript File	22424-Review.docx
Answering Reviewers	22424-Answering reviewers .pdf
Audio Core Tip	22424-Audio core tip.aif
Conflict-of-Interest Disclosure Form	22424-Conflict-of-interest statement.pdf
Copyright License Agreement	22424-Copyright assignment.pdf
Peer-review Report	22424-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	22424-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	22424-Scientific misconduct check.pdf
Scientific Editor Work List	22424-Scientific editor work list.pdf