Publication Name	World Journal of Hypertension
Manuscript ID	22895
Country	United States

Received	2015-09-30 16:21
Peer-Review Started	2015-10-08 10:03
To Make the First Decision	2015-11-06 11:11
Return for Revision	2015-11-10 10:21
Revised	2015-11-24 12:58
Second Decision	2016-01-12 16:34
Accepted by Journal Editor-in-Chief	2016-01-12 21:24
Accepted by Company Editor-in-Chief	2016-01-22 16:29
Articles in Press	2016-01-22 16:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-19 11:13
Publish the Manuscript Online	2016-02-23 22:08

ISSN	2220-3168 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	RhoA signaling and blood pressure: The consequence of failing to “Tone it Down”
Manuscript Source	Invited Manuscript
All Author List	Xue Bai, Rachel Dee, Kevin D Mangum, Christopher P Mack and Joan M Taylor
Funding Agency and Grant Number	Funding Agency Grant Number National Heart, Lung, and Blood Institute, National Institutes of Health to Taylor JM HL-081844 National Heart, Lung, and Blood Institute, National Institutes of Health to Taylor JM HL-071054 Muscular Dystrophy Association to Taylor JM MDA255577
Corresponding Author	Joan M Taylor, PhD, Department of Pathology and Laboratory Medicine, McAllister Heart Institute, University of North Carolina at Chapel Hill, CB7525, 501 Brinkhous-Bullitt Bld, Chapel Hill, NC 27599, United States. jmt3x@med.unc.edu
Key Words	Hypertension; Blood pressure; RhoA; Smooth muscle contraction; Guanine nucleotide ex­change factor; GTPase activating protein; Polymor­phisms
Core Tip	Studies (primarily in pre-clinical models) indicate that the small GTPase RhoA and its downstream target, Rho kinase, play an important role in regulating blood pressure homeostasis. Herein, we summarize the underlying mechanisms and highlight signaling pathways and regulators that impart tight spatial-temporal control of RhoA activity. We also discuss known allelic varia-tions in the RhoA pathway and consider how these polymorphisms may affect genetic risk for hypertension and its clinical manifestations. Finally, we summarize the current (albeit limited) clinical data on the efficacy of targeting the RhoA pathway in hypertensive patients.
Publish Date	2016-02-23 22:08
Citation	Bai X, Dee R, Mangum KD, Mack CP, Taylor JM. RhoA signaling and blood pressure: The consequence of failing to “Tone it Down”. World J Hypertens 2016; 6(1): 18-35
URL	http://www.wjgnet.com/2220-3168/full/v6/i1/18.htm
DOI	http://dx.doi.org/10.5494/wjh.v6.i1.18

Full Article (PDF)	WJH-6-18.pdf
Full Article (Word)	WJH-6-18.doc
Manuscript File	22895-Review.docx
Answering Reviewers	22895-Answering reviewers.pdf
Audio Core Tip	22895-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22895-Conflict-of-interest statement.pdf
Copyright License Agreement	22895-Copyright assignment.pdf
Peer-review Report	22895-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	22895-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	22895-Scientific misconduct check.pdf
Scientific Editor Work List	22895-Scientific editor work list.pdf