Publication Name	World Journal of Diabetes
Manuscript ID	22913
Country	Japan

Received	2015-10-02 13:19
Peer-Review Started	2015-10-09 17:52
First Decision by Editorial Office Director
Return for Revision	2015-11-10 10:35
Revised	2015-11-24 17:18
Publication Fee Transferred
Second Decision by Editor	2016-02-17 09:14
Second Decision by Editor-in-Chief	2016-02-17 21:59
Final Decision by Editorial Office Director	2016-05-27 11:30
Articles in Press	2016-05-27 11:30
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-06-30 14:00
Publish the Manuscript Online	2016-07-06 13:52

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Role of bile acids in the regulation of the metabolic pathways
Manuscript Source	Invited Manuscript
All Author List	Hiroki Taoka, Yoko Yokoyama, Kohkichi Morimoto, Naho Kitamura, Tatsuya Tanigaki, Yoko Takashina, Kazuo Tsubota and Mitsuhiro Watanabe
Funding Agency and Grant Number
Corresponding Author	Mitsuhiro Watanabe, PhD, Professor of Graduate School of Media and Governance, Professor of Faculty of Environment and Information Studies, Graduate School of Media and Governance, Department of Environment and Information Studies, Keio University, tau42, 5322 Endo, Fujisawa, Kanagawa 252-0882, Japan. wmitsu@sfc.keio.ac.jp
Key Words	Bile acids; TGR5/M-BAR; Farnesoid X receptor; Glucose metabolism; Energy metabolism; Lipid metabolism; Bariatric surgery; Microbiota; Incretin; Bile acid binding resin
Core Tip	Bile acids (BAs) are important molecules that participate in various metabolic pathways. BA signaling mechanisms are attractive therapeutic targets of the metabolic syndrome. In this review, we show the mecha-nisms of controlling glucose, lipid and energy metabolism via BA signaling. Furthermore, the authors also describe how those basic scientific studies have been applied to the clinical setting. Particularly, bile acid binding resin (BABR) originally used to treat hypercholesterolemia also stimulates incretin secretion and improves glucose metabolism. In addition to BABR, the clinical application of farnesoid X receptor and TGR5/M-BAR agonists are ongoing for the treatment of metabolic syndrome. The effects of bariatric surgery on glycemic control are also associated with BA metabolism.
Publish Date	2016-07-06 13:52
Citation	Taoka H, Yokoyama Y, Morimoto K, Kitamura N, Tanigaki T, Takashina Y, Tsubota K, Watanabe M. Role of bile acids in the regulation of the metabolic pathways. World J Diabetes 2016; 7(13): 260-270
URL	http://www.wjgnet.com/1948-9358/full/v7/i13/260.htm
DOI	http://dx.doi.org/10.4239/wjd.v7.i13.260

Full Article (PDF)	WJD-7-260.pdf
Full Article (Word)	WJD-7-260.doc