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4/20/2016 1:41:00 PM | Browse: 1402 | Download: 2691
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Received |
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2015-10-05 14:05 |
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Peer-Review Started |
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2015-10-05 16:25 |
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To Make the First Decision |
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2015-11-24 14:41 |
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Return for Revision |
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2015-11-27 08:29 |
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Revised |
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2015-12-14 23:39 |
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Second Decision |
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2016-01-22 15:10 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-01-31 14:22 |
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Articles in Press |
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2016-01-31 14:22 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-04-06 11:42 |
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Publish the Manuscript Online |
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2016-04-11 10:17 |
| ISSN |
2220-6132 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, General & Internal |
| Manuscript Type |
Basic Study |
| Article Title |
Prednisolone inhibits SaOS2 osteosarcoma cell proliferation by activating inducible nitric oxide synthase
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Alessandra Cazzaniga, Jeanette AM Maier and Sara Castiglioni |
| Funding Agency and Grant Number |
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| Corresponding Author |
Dr. Jeanette AM Maier, Dipartimento di Scienze Biomediche e Cliniche Luigi Sacco, Università di Milano, via GB Grassi 74, 20157 Milano,
Italy. jeanette.maier@unimi.it
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| Key Words |
Osteosarcoma cells; Prednisolone; Nitric oxide; Inducible nitric oxide synthase; Endothelial nitric oxide synthase; Reactive oxygen species |
| Core Tip |
Since prednisolone, a widely used synthetic glucocorticoid, inhibits osteoblast proliferation, we evaluated its effects on osteosarcoma cells. In particular, we used two osteoblastic osteosarcoma cell lines with different degree of differentiation, i.e., SaOS2, which have a rather mature phenotype, and U2OS, which are less differentiated. We found that prednisolone inhibited SaOS2 proliferation by increasing the release of nitric oxide (NO) through the upregulation of inducible NO synthase (iNOS). Indeed, pharmacological inhibition with the iNOS inhibitor l-N6-(iminoethyl)-lysine-HCl restored the normal pro-liferation rate of the SaOS2. On the contrary, predni-solone did not modulate NO production nor cell growth in U2OS.
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| Publish Date |
2016-04-11 10:17 |
| Citation |
Cazzaniga A, Maier JAM, Castiglioni S. Prednisolone inhibits SaOS2 osteosarcoma cell proliferation by activating inducible nitric oxide synthase. World J Transl Med 2016; 5(1): 53-58 |
| URL |
http://www.wjgnet.com/2220-6132/full/v5/i1/53.htm |
| DOI |
http://dx.doi.org/10.5528/wjtm.v5.i1.53 |
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