Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	23127
Country	China

Received	2015-11-02 14:15
Peer-Review Started	2015-11-03 17:15
To Make the First Decision	2015-12-18 17:18
Return for Revision	2015-12-21 13:57
Revised	2016-01-11 14:14
Second Decision	2016-01-22 15:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-01-31 14:26
Articles in Press	2016-01-31 14:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-04-10 19:34
Publish the Manuscript Online	2016-04-20 11:37

ISSN	1948-9366 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Research & Experimental Medicine
Manuscript Type	Basic Study
Article Title	Effect of Roux-en-Y gastric bypass surgery on intestinal Akkermansia muciniphila
Manuscript Source	Unsolicited Manuscript
All Author List	Ming Yan, Mao-Min Song, Ri-Xing Bai, Shi Cheng and Wen-Mao Yan
Funding Agency and Grant Number
Corresponding Author	Mao-Min Song, Professor, Department of General Surgery, Beijing Tiantan Hospital, Capital Medical University, No. 6, Tiantanxili Road, Beijing 100050, China. dryanming@hotmail.com
Key Words	Roux-en-Y gastric bypass surgery; Type 2 diabetes; Glucagon-like peptide-1; Glucose-dependent insulinotropic peptide; Akkermansia mucinipilia
Core Tip	Roux-en-Y gastric bypass (RYGB) surgery can improve blood glucose with definite efficacy in obese patients with type 2 diabetes mellitus and that this effect is also long lasting. But the mechanism of RYGB is not clear. Our study demonstrated RYGB surgery may increase glucagon-like peptide-1 (GLP-1) secretion, elevate serum insulin after intragastric injection of glucose, and improve insulin resistance in diabetic Goto-Kakizaki rats, thereby contributing to a significant reduction in blood glucose. The increased amount of Akkermansia muciniphila after RYGB surgery may be related to elevated GLP-1 secretion.
Publish Date	2016-04-20 11:37
Citation	Yan M, Song MM, Bai RX, Cheng S, Yan WM. Effect of Roux-en-Y gastric bypass surgery on intestinal Akkermansia muciniphila. World J Gastrointest Surg 2016; 8(4): 301-307
URL	http://www.wjgnet.com/1948-9366/full/v8/i4/301.htm
DOI	http://dx.doi.org/10.4240/wjgs.v8.i4.301

Full Article (PDF)	WJGS-8-301.pdf
Full Article (Word)	WJGS-8-301.doc
Manuscript File	23127-Review.doc
Answering Reviewers	23127-Answering reviewers.pdf
Audio Core Tip	23127-Audio core tip.mp3
Biostatistics Review Certificate	23127-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	23127-Conflict-of-interest statement.pdf
Copyright License Agreement	23127-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	23127-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	23127-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	23127-Language certificate.pdf
Peer-review Report	23127-Peer-review(s).pdf
Scientific Misconduct Check	23127-Scientific misconduct check.pdf
Scientific Editor Work List	23127-Scientific editor work list.pdf