| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Combined acoustic radiation force impulse, aminotransferase to platelet ratio index and Forns index assessment for hepatic fibrosis grading in hepatitis B
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Chang-Feng Dong, Jia Xiao, Ling-Bo Shan, Han-Ying Li, Yong-Jia Xiong, Gui-Lin Yang, Jing Liu, Si-Min Yao, Sha-Xi Li, Xiao-Hua Le, Jing Yuan, Bo-Ping Zhou, George L Tipoe and Ying-Xia Liu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shenzhen Municipal Science and Technology Innovation Fund |
CXZZ20130322170220544 |
| Shenzhen Municipal Science and Technology Innovation Fund |
JCYJ20140411112047885 |
|
| Corresponding Author |
George L Tipoe, MD, PhD, School of Biomedical Sciences, LKS Faculty of Medicine, the University of Hong Kong, Pokfulam, Hong Kong, China. tgeorge@hku.hk
|
| Key Words |
Acoustic radiation force impulse; Aspartate aminotransferase to platelet ratio index; Forns index; Hepatitis B virus; Non-invasive diagnosis |
| Core Tip |
Chronic hepatitis B (CHB) is a major health problem in a lot of countries all over the world, parti-cularly in China. An accurate staging of liver fibrosis is critical for prognosticating this disease. However, although it is still the golden standard, liver biopsy is hindered by its inherent drawbacks in clinical appli-cations. In this study, we demonstrated that non-invasive methods, including acoustic radiation force impulse (ARFI), aspartate aminotransferase to platelet ratio index (APRI) and Forns index showed significant correlations with the histological staging results from liver biopsy. The combined measurement of ARFI and APRI had the best diagnostic accuracy, which provided an ideal and convenient non-invasive diagnostic method for the detection of hepatic fibrosis of CHB patients in clinical practice.
|
| Publish Date |
2016-05-12 10:37 |
| Citation |
Dong CF, Xiao J, Shan LB, Li HY, Xiong YJ, Yang GL, Liu J, Yao SM, Li SX, Le XH, Yuan J, Zhou BP, Tipoe GL, Liu YX. Combined acoustic radiation force impulse, aminotransferase to platelet ratio index and Forns index assessment for hepatic fibrosis grading in hepatitis B. World J Hepatol 2016; 8(14): 616-624 |
| URL |
http://www.wjgnet.com/1948-5182/full/v8/i14/616.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v8.i14.616 |
