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7/6/2016 5:03:00 PM | Browse: 424 | Download: 1184
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Received |
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2016-02-01 09:14 |
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Peer-Review Started |
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2016-02-01 17:10 |
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To Make the First Decision |
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2016-03-25 14:31 |
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Return for Revision |
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2016-03-25 16:27 |
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Revised |
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2016-04-30 21:48 |
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Second Decision |
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2016-05-18 08:58 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-06-03 16:12 |
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Articles in Press |
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2016-06-03 16:12 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-06-24 09:43 |
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Publish the Manuscript Online |
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2016-07-06 09:19 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Basic Study |
| Article Title |
Assembly and release of infectious hepatitis C virus involving unusual organization of the secretory pathway
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Miriam Triyatni, Edward A Berger and Bertrand Saunier |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Intramural Program of the National Institutes of Health, National Institute of Allergy and Infectious Diseases |
1 ZIA AI000733-15 |
| RISE Senior Fellow award |
1238-1238-03 |
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| Corresponding Author |
Bertrand Saunier, MD, PhD, Unité de Virologie Structurale, Institut Pasteur and CNRS UMR 3569, Centre François Jacob, 28 rue du Docteur Roux, 75724 Paris,
France. bsaunier@pasteur.fr |
| Key Words |
Membrane rearrangements; Hepatitis C virus; Flavivirus replicon; Virus assembly and secretion; Host cellular factors |
| Core Tip |
Our system for production of authentic infec-tious hepatitis C virus (HCV) in non-humanized, non-hepatic cells involves the rearrangement of inner cellular membranes triggered by the replication of flaviviruses. The present results suggest that this feature relies on the re-wiring of host factors that usually contribute to the secretion of glycoproteins to generate an unusual secretory pathway. This model offers a new way to study the properties of free HCV particles, i.e., indepen-dently from lipoproteins. |
| Publish Date |
2016-07-06 09:19 |
| Citation |
Triyatni M, Berger EA, Saunier B. Assembly and release of infectious hepatitis C virus involving unusual organization of the secretory pathway. World J Hepatol 2016; 8(19): 796-814 |
| URL |
http://www.wjgnet.com/1948-5182/full/v8/i19/796.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v8.i19.796 |
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