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6/2/2016 5:31:00 PM | Browse: 550 | Download: 1631
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Received |
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2016-02-12 10:14 |
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Peer-Review Started |
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2016-02-12 19:45 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2016-03-11 12:50 |
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Revised |
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2016-04-01 18:43 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2016-04-06 12:11 |
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Second Decision by Editor-in-Chief |
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2016-04-08 11:22 |
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Final Decision by Editorial Office Director |
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2016-04-22 16:56 |
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Articles in Press |
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2016-04-22 16:56 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-05-19 09:53 |
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Publish the Manuscript Online |
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2016-06-02 15:41 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Maria Nicoline Baandrup Kristiansen, Sanne Skovgård Veidal, Kristoffer Tobias Gustav Rigbolt, Kirstine Sloth Tølbøl, Jonathan David Roth, Jacob Jelsing, Niels Vrang and Michael Feigh |
| Funding Agency and Grant Number |
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| Corresponding Author |
Michael Feigh, PhD, Gubra Aps, Hørsholm Kongevej 11B, 2970 Hørsholm,
Denmark. mfe@gubra.dk
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| Key Words |
Nonalcoholic steatohepatitis; Liver biopsy; Diet-induced obesity; Nonalcoholic fatty liver disease; Fibrosis |
| Core Tip |
We characterize the development and pro-gression of diet-induced nonalcoholic steatohepatitis (NASH) in a wild-type and a genetically obese mouse model. We confirm that a diet high in trans-fat, fructose and cholesterol, develops key histological hallmarks of NASH (steatosis, inflammation, ballooning degeneration) in conjunction with fibrosis. Concomitantly, marked alterations in NASH associated gene expression path-ways can be evaluated by RNAseq analysis. In addition, we describe that performing a baseline liver biopsy enables individual disease staging for subsequent stratified randomization of animals into study groups. Finally, we show these models′ utility for a chronic repeated dosing study to evaluate pharmacological intervention.
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| Publish Date |
2016-06-02 15:41 |
| Citation |
Kristiansen MNB, Veidal SS, Rigbolt KTG, Tølbøl KS, Roth JD, Jelsing J, Vrang N, Feigh M. Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy. World J Hepatol 2016; 8(16): 673-684
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| URL |
http://www.wjgnet.com/1948-5182/full/v8/i16/673.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v8.i16.673 |
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