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6/21/2016 8:27:00 AM | Browse: 627 | Download: 1457
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Received |
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2016-02-12 10:37 |
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Peer-Review Started |
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2016-02-14 16:41 |
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To Make the First Decision |
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2016-03-01 09:22 |
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Return for Revision |
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2016-03-01 16:48 |
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Revised |
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2016-03-01 19:58 |
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Second Decision |
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2016-03-07 15:56 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-03-18 16:03 |
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Articles in Press |
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2016-03-18 16:03 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-05-16 15:10 |
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Publish the Manuscript Online |
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2016-06-01 11:12 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Control Study |
| Article Title |
Genetic polymorphisms of interleukin 1β gene and sporadic pancreatic neuroendocrine tumors susceptibility
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Dimitrios Karakaxas, Anna Sioziou, Gerasimos Aravantinos, Ahmet Coker, Ioannis S Papanikolaou, Theodoros Liakakos, Christos Dervenis and Maria Gazouli |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Hellenic Society of Medical Oncology |
5839/08-04-2015 |
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| Corresponding Author |
Maria Gazouli, PhD, Assistant Professor of Molecular Biology, Department of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Michalakopoulou 176, 11527 Athens, Greece. mgazouli@med.uoa.gr |
| Key Words |
Interleukin 1β; Neuroendocrine tumors; Pancreas |
| Core Tip |
Pancreatic neuroendocrine tumors (pNETs) are a heterogeneous group of rare neoplasms derived from pancreatic endocrine cells and have significantly different tumor biology and present better prognosis compared with tumors of the exocrine pancreas, like pancreatic adenocarcinomas. It is widely accepted that chronic inflammation contributes to pathogenesis of many pancreatic diseases, including pancreatic carcinogenesis. Interleukin 1β (IL-1β) is a highly active pro-inflammatory cytokine with multiple biological effects, such as directing cancer cells to either neuroendocrine differentiation or to development of adenocarcinoma. The purpose of the study was to evaluate the association between the IL-1β polymorphisms and the pNET development. |
| Publish Date |
2016-06-01 11:12 |
| Citation |
Karakaxas D, Sioziou A, Aravantinos G, Coker A, Papanikolaou IS, Liakakos T, Dervenis C, Gazouli M. Genetic polymorphisms of interleukin 1β gene and sporadic pancreatic neuroendocrine tumors susceptibility. World J Gastrointest Oncol 2016; 8(6): 520-525 |
| URL |
http://www.wjgnet.com/1948-5204/full/v8/i6/520.htm |
| DOI |
http://dx.doi.org/10.4251/wjgo.v8.i6.520 |
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