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6/14/2016 4:55:00 PM | Browse: 498 | Download: 1023
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Received |
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2016-02-26 08:33 |
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Peer-Review Started |
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2016-02-26 17:05 |
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To Make the First Decision |
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2016-03-23 17:34 |
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Return for Revision |
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2016-03-25 19:58 |
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Revised |
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2016-05-03 03:39 |
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Second Decision |
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2016-05-09 08:48 |
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Accepted by Journal Editor-in-Chief |
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2016-05-09 16:13 |
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Accepted by Executive Editor-in-Chief |
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2016-05-27 10:21 |
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Articles in Press |
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2016-05-27 10:21 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-05-31 10:08 |
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Publish the Manuscript Online |
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2016-06-14 15:22 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Circulating insulin-like growth factor-binding protein 3 as prognostic biomarker in liver cirrhosis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Carina Gabriela Correa, Bruno da Silveira Colombo, Marcelo Fernando Ronsoni, Pedro Eduardo Soares e Silva, Leonardo Fayad, Telma Erotides Silva, Letícia Muraro Wildner, Maria Luiza Bazzo, Esther Buzaglo Dantas-Correa, Janaína Luz Narciso-Schiavon and Leonardo de Lucca Schiavon |
| Funding Agency and Grant Number |
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| Corresponding Author |
Dr. Leonardo de Lucca Schiavon, Division of Gastroenterology, Federal University of Santa Catarina, Rua Deputado Antonio Edu Vieira 1310, casa 217, Bairro Pantanal, Florianópolis, Santa Catarina 88.040-001,
Brazil. leo-jf@uol.com.br
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| Key Words |
Liver cirrhosis; Acute decompensation; Insulin-like growth factor binding protein 3; Acute-on-chronic liver failure; Prognosis |
| Core Tip |
Insulin-like growth factor-binding protein 3 (IGFBP-3) levels are decreased in cirrhosis and seem to correlate with the intensity of hepatic dysfunction, but its prognostic significance is uncertain. In this prospective cohort study, IGFBP-3 levels correlated with variables associated with the intensity of liver dysfunction in both outpatients with stable cirrhosis and in subjects hospitalized for acute decompensation. IGFBP-3 levels increased significantly after discharge and after liver transplantation. Lower IGFBP-3 levels were associated with poor outcomes in both outpatients with stable cirrhosis and in those hospitalized for acute decompensation, suggesting that it can be used in clinical practice as a prognostic biomarker in cirrhosis.
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| Publish Date |
2016-06-14 15:22 |
| Citation |
Correa CG, Colombo BS, Ronsoni MF, Soares e Silva PE, Fayad L, Silva TE, Wildner LM, Bazzo ML, Dantas-Correa EB, Narciso-Schiavon JL, Schiavon LL. Circulating insulin-like growth factor-binding protein 3 as prognostic biomarker in liver cirrhosis. World J Hepatol 2016; 8(17): 739-748 |
| URL |
http://www.wjgnet.com/1948-5182/full/v8/i17/739.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v8.i17.739 |
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