Publication Name	World Journal of Cardiology
Manuscript ID	25317
Country	United Kingdom

Received	2016-03-04 09:14
Peer-Review Started	2016-03-04 15:46
First Decision by Editorial Office Director
Return for Revision	2016-03-22 09:12
Revised	2016-04-04 21:59
Publication Fee Transferred
Second Decision by Editor	2016-04-06 16:57
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2016-04-18 11:58
Articles in Press	2016-04-18 11:58
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-05-06 16:01
Publish the Manuscript Online	2016-05-20 11:59

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Basic Study
Article Title	Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4
Manuscript Source	Invited Manuscript
All Author List	Azhar Maqbool, Emma J Spary, Iain W Manfield, Michaela Ruhmann, Lorena Zuliani-Alvarez, Filomena O Gamboa-Esteves, Karen E Porter, Mark J Drinkhill, Kim S Midwood and Neil A Turner
Funding Agency and Grant Number	Funding Agency Grant Number British Heart Foundation CH/92005
Corresponding Author	Azhar Maqbool, PhD, Lecturer in Cardiovascular Medicine, Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Clarendon Way, Leeds LS2 9JT, United Kingdom. cvsam@leeds.ac.uk
Key Words	Tenascin C; Matrix metalloproteinase; Toll-like receptor; Interleukin-6; Cardiac fibroblasts
Core Tip	Tenascin C (TNC) is transiently expressed in cardiac tissue following acute myocardial infarction (MI) and MI patients with higher serum TNC levels have worse long term prognosis. This suggests that TNC is important in ventricular remodelling, although a functional role in this process is unclear. We report that TNC stimulates interleukin-6 synthesis in cardiac myofibroblasts, an effect mediated by toll-like receptor 4. As a growing body of evidence suggests that prolongation of the post-infarction inflammatory response results in worse remodelling and dysfunction this important observation may in part explain the mechanism by which TNC induces maladaptive ventricular remodelling following MI.
Publish Date	2016-05-20 11:59
Citation	Maqbool A, Spary EJ, Manfield IW, Ruhmann M, Zuliani-Alvarez L, Gamboa-Esteves FO, Porter KE, Drinkhill MJ, Midwood KS, Turner NA. Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4. World J Cardiol 2016; 8(5): 340-350
URL	http://www.wjgnet.com/1949-8462/full/v8/i5/340.htm
DOI	http://dx.doi.org/10.4330/wjc.v8.i5.340

Full Article (PDF)	WJC-8-340.pdf
Full Article (Word)	WJC-8-340.doc