Publication Name	World Journal of Hepatology
Manuscript ID	25383
Country	Egypt

Received	2016-03-07 08:58
Peer-Review Started	2016-03-07 11:14
To Make the First Decision	2016-05-17 12:16
Return for Revision	2016-05-18 10:39
Revised	2016-06-01 21:24
Second Decision	2016-06-30 08:35
Accepted by Journal Editor-in-Chief	2016-06-30 11:26
Accepted by Executive Editor-in-Chief	2016-07-13 12:06
Articles in Press	2016-07-13 12:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-27 16:03
Publish the Manuscript Online	2016-08-17 08:44

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Interplay between microRNA-17-5p, insulin-like growth factor-Ⅱ through binding protein-3 in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Danira Ashraf Habashy, Hend Mohamed El Tayebi, Injie Omar Fawzy, Karim Adel Hosny, Gamal Esmat and Ahmed Ihab Abdelaziz
Funding Agency and Grant Number
Corresponding Author	Ahmed Ihab Abdelaziz, MD, PhD, Associate Professor of Molecular Medicine, Department of Bio­logy, American University in Cairo, New Cairo City, AUC Avenue, Cairo 11835, Egypt. ahmed.ihab.abdelaziz@gmail.com
Key Words	Insulin-like growth factor binding protein-3; Insulin-like growth factor signaling pathway; microRNA; Insulin-like growth factor-Ⅱ; Hepatocellular carcinoma
Core Tip	microRNA-17-5p (miR-17-5p) was extensively underexpressed in hepatocellular carcinoma tissues, while insulin-like growth factor binding protein-3 (IGFBP-3) mRNA showed significant upregulation in the same set of patients. In HuH-7 cell line, miR-17-5p directly targets and downregulates IGFBP-3, consequently elevating the level of free insulin-like growth factor-Ⅱ (IGF-Ⅱ). Thus, manipulation of microRNAs can potentially control the activation of the oncogenic IGF axis.
Publish Date	2016-08-17 08:44
Citation	Habashy DA, El Tayebi HM, Fawzy IO, Hosny KA, Esmat G, Abdelaziz AI. Interplay between microRNA-17-5p, insulin-like growth factor-Ⅱ through binding protein-3 in hepatocellular carcinoma. World J Hepatol 2016; 8(23): 976-984
URL	http://www.wjgnet.com/1948-5182/full/v8/i23/976.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i23.976

Full Article (PDF)	WJH-8-976.pdf
Full Article (Word)	WJH-8-976.doc
Manuscript File	25383-Review.doc
Answering Reviewers	25383-Answering reviewers.pdf
Audio Core Tip	25383-Audio core tip.mp3
Biostatistics Review Certificate	25383-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	25383-Conflict-of-interest statement.pdf
Copyright License Agreement	25383-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20160306202722.pdf
Institutional Review Board Approval Form or Document	25383-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	25383-Language certificate.pdf
Peer-review Report	25383-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	25383-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	25383-Scientific misconduct check.pdf
Scientific Editor Work List	25383-Scientific editor work list.pdf