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12/15/2016 5:39:00 PM | Browse: 745 | Download: 1405
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Received |
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2016-03-23 10:03 |
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Peer-Review Started |
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2016-03-23 11:20 |
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To Make the First Decision |
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2016-07-04 16:49 |
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Return for Revision |
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2016-07-05 09:51 |
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Revised |
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2016-07-15 16:51 |
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Second Decision |
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2016-09-05 09:43 |
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Accepted by Journal Editor-in-Chief |
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2016-09-06 19:00 |
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Accepted by Executive Editor-in-Chief |
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2016-09-18 14:15 |
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Articles in Press |
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2016-09-18 14:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-12-07 18:12 |
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Publish the Manuscript Online |
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2016-12-15 16:07 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Primary liver injury and delayed resolution of liver stiffness after alcohol detoxification in heavy drinkers with the <i>PNPLA3</i> variant I148M
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Vanessa Rausch, Teresa Peccerella, Carolin Lackner, Eray Yagmur, Helmut-Karl Seitz, Thomas Longerich and Sebastian Mueller |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| German Research Foundation |
DFG, RA-2677/1-1 |
| Dietmar Hopp-Foundation |
2301196 |
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| Corresponding Author |
Sebastian Mueller, MD, PhD, Salem Medical Center and Center for Alcohol Research, University of Heidelberg, Zeppelinstraße 11-33, 69120 Heidelberg,
Germany. sebastian.mueller@urz.uni-heidelberg.de |
| Key Words |
Liver stiffness; Alcoholic liver disease; Adiponutrin; <i>PNPLA3</i>; Transient elastography; Alcohol withdrawal; Inflammation |
| Core Tip |
The role of the <i>PNPLA3</i> rs738409 variant (CG and GG) on histology and liver stiffness in response to alcohol detoxification was studied in a large monocentric cohort of heavy drinkers with various stages of ALD. About 20% of our patients with alcoholic liver cirrhosis were attributable to <i>PNPLA3</i> G variants with an OR to develop cirrhosis of 1.295. Our data further show that <i>PNPLA3</i> GG carriers primarily develop ballooning and not steatosis causing a delayed resolution of liver stiffness after alcohol withdrawal. We suggest that the delayed ballooning-associated stiffness elevation may contribute to fibrosis progression (see also the sinusoidal pressure hypothesis). |
| Publish Date |
2016-12-15 16:07 |
| Citation |
Rausch V, Peccerella T, Lackner C, Yagmur E, Seitz HK, Longerich T, Mueller S. Primary liver injury and delayed resolution of liver stiffness after alcohol detoxification in heavy drinkers with the PNPLA3 variant I148M. World J Hepatol 2016; 8(35): 1547-1556 |
| URL |
http://www.wjgnet.com/1948-5182/full/v8/i35/1547.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v8.i35.1547 |
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