Publication Name	World Journal of Gastroenterology
Manuscript ID	26105
Country	Japan

Received	2016-03-29 09:39
Peer-Review Started	2016-04-01 13:20
First Decision by Editorial Office Director
Return for Revision	2016-05-13 16:09
Revised	2016-05-25 13:24
Publication Fee Transferred
Second Decision by Editor	2016-06-08 18:27
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2016-06-15 18:20
Articles in Press	2016-06-15 18:20
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-07 10:00
Publish the Manuscript Online	2016-07-15 15:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Diabetes mellitus and metformin in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Koji Fujita, Hisakazu Iwama, Hisaaki Miyoshi, Joji Tani, Kyoko Oura, Tomoko Tadokoro, Teppei Sakamoto, Takako Nomura, Asahiro Morishita, Hirohito Yoneyama and Tsutomu Masaki
Funding Agency and Grant Number
Corresponding Author	Tsutomu Masaki, Professor, Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Ikenobe 1750-1, Miki, Kita, Kagawa 760-8521, Japan. tmasaki@med.kagawa-u.ac.jp
Key Words	Hepatocellular carcinoma; Diabetes mellitus; Metformin; Risk
Core Tip	Diabetes mellitus, an increasing risk factor for hepatocellular carcinoma (HCC), shares pathological mechanisms with HCC. Thus, the first-line anti-diabetic metformin was anticipated to reduce cancer risk. Though basic research has provided evidence of its anti-cancer effect, clinical studies of diabetic patients have not provided conclusive data that metformin reduces HCC risk. Clinical studies have suggested that metformin may suppress cancer in non-diabetic subjects. Basic research on cancer stem cell-targeting therapies has also examined the potential of metformin.
Publish Date	2016-07-15 15:38
Citation	Fujita K, Iwama H, Miyoshi H, Tani J, Oura K, Tadokoro T, Sakamoto T, Nomura T, Morishita A, Yoneyama H, Masaki T. Diabetes mellitus and metformin in hepatocellular carcinoma. World J Gastroenterol 2016; 22(27): 6100-6113
URL	http://www.wjgnet.com/1007-9327/full/v22/i27/6100.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i27.6100

Full Article (PDF)	WJG-22-6100.pdf
Full Article (Word)	WJG-22-6100.doc
Manuscript File	26105-Review.docx
Answering Reviewers	26105-Answering reviewers.pdf
Audio Core Tip	26105-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26105-Conflict-of-interest statement.pdf
Copyright License Agreement	26105-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	26105-Language certificate.pdf
Peer-review Report	26105-Peer-review(s).pdf
Scientific Misconduct Check	26105-Scientific misconduct check.pdf
Scientific Editor Work List	26105-Scientific editor work list.pdf