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8/3/2016 5:07:00 PM | Browse: 429 | Download: 690
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Received |
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2016-04-01 09:05 |
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Peer-Review Started |
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2016-04-06 16:45 |
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To Make the First Decision |
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2016-05-17 12:16 |
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Return for Revision |
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2016-05-18 18:10 |
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Revised |
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2016-06-07 20:34 |
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Second Decision |
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2016-06-30 08:39 |
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Accepted by Journal Editor-in-Chief |
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2016-07-01 08:33 |
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Accepted by Company Editor-in-Chief |
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2016-07-13 12:16 |
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Articles in Press |
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2016-07-13 12:16 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-07-25 12:10 |
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Publish the Manuscript Online |
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2016-08-03 08:12 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Cholesterol metabolism in cholestatic liver disease and liver transplantation: From molecular mechanisms to clinical implications
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Katriina Nemes, Fredrik Åberg, Helena Gylling and Helena Isoniemi |
| Funding Agency and Grant Number |
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| Corresponding Author |
Katriina Nemes, MD, PhD, University of Helsinki and Helsinki University Central Hospital, Transplantation and Liver Surgery Clinic, Meilahti Hospital, P.O. BOX 340, FI-00029 HUS, Finland. katriina.nemes@outlook.com |
| Key Words |
Cholesterol metabolism; Cholestasis; Liver transplantation; Non-cholesterol sterols; Cholestanol; Donor; Low density lipoprotein receptor mutation; Apolipoprotein B-100; Lipoprotein-X |
| Core Tip |
The liver plays key roles in cholesterol meta-bolism. Cholestatic liver disease leads to alterations of cholesterol metabolism: Cholesterol homeostasis is disturbed and cholesterol synthesis and especially cholesterol absorption are reduced, and lipoprotein X may develop. The latter can interfere with cardiovascular risk assessment. Apolipoprotein B-100 measurement may be useful in such cases. Cholesterol metabolism in cholestasis could be better described using cholesterol precursor sterols, diet-derived plant sterols, and cho-lestanol (the liver-synthesized derivate of cholesterol). Accurate lipid profile evaluation is particularly important after liver transplantation, when both atherogenic and non-atherogenic hypercholesterolemia may co-exist. |
| Publish Date |
2016-08-03 08:12 |
| Citation |
Nemes K, Åberg F, Gylling H, Isoniemi H. Cholesterol metabolism in cholestatic liver disease and liver transplantation: From molecular mechanisms to clinical implications. World J Hepatol 2016; 8(22): 924-932 |
| URL |
http://www.wjgnet.com/1948-5182/full/v8/i22/924.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v8.i22.924 |
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