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8/17/2016 5:16:00 PM | Browse: 498 | Download: 875
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Received |
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2016-04-07 08:58 |
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Peer-Review Started |
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2016-04-07 10:10 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2016-05-26 14:23 |
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Revised |
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2016-06-02 00:00 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2016-06-20 08:17 |
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Second Decision by Editor-in-Chief |
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2016-06-20 18:16 |
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Final Decision by Editorial Office Director |
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2016-06-28 15:52 |
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Articles in Press |
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2016-06-28 15:52 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-08-04 15:21 |
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Publish the Manuscript Online |
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2016-08-15 10:30 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Mitochondrial DNA from hepatocytes as a ligand for TLR9: Drivers of nonalcoholic steatohepatitis?
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Priya Handa, Akhila Vemulakonda, Kris V Kowdley, Misael Uribe and Nahum Méndez-Sánchez |
| Funding Agency and Grant Number |
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| Corresponding Author |
Priya Handa, MS, PhD, Senior Research Scientist, Organ Care Research and Liver Care Network, 1124 Columbia Street, Suite 600, Swedish Medical Center, Seattle, WA 98104, United States. priya.handa@swedish.org |
| Key Words |
TLR9; Damage-associated molecular patterns; Products of microbial metabolism produced by pathogens; Mitochondrial DNA; Hepatocytes; Nonalcoholic steatohepatitis; Nonalcoholic fatty liver disease; Inflammation; Innate immune signaling; Kupffer cells; Therapy |
| Core Tip |
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease. It has been shown that innate immune activation contributes to the progression of NAFLD by inducing hepatic inflammation. A new study recently demonstrated that hepatocyte mitochondrial DNA acts as a damage -induced molecular pattern activating hepatic TLR9 to initiate and amplify inflammatory signaling leading to nonalcoholic steatohepatitis (NASH). Inhibiting TLR9 by using a synthetic antagonist, IRS 954, reversed steatohepatitis; as did a whole body ablation of TLR9 or a myeloid-specific knockout of TLR9. This editorial summarizes the findings of the new study and describes potential novel therapeutic targets that may hold promise for NASH treatment.
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| Publish Date |
2016-08-15 10:30 |
| Citation |
Handa P, Vemulakonda A, Kowdley KV, Uribe M, Mendez-Sanchez N. Mitochondrial DNA from hepatocytes as a ligand for TLR9: Drivers of nonalcoholic steatohepatitis? World J Gastroenterol 2016; 22(31): 6965-6971 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i31/6965.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i31.6965 |
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