Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	26791
Country	United States

Received	2016-04-26 17:41
Peer-Review Started	2016-04-28 08:44
To Make the First Decision	2016-06-12 09:17
Return for Revision	2016-06-16 11:16
Revised	2016-07-01 05:13
Second Decision	2016-07-14 14:59
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-07-22 11:22
Articles in Press	2016-07-22 11:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-07-27 16:37
Publish the Manuscript Online	2016-08-10 15:41

ISSN	2150-5330 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Pathology
Manuscript Type	Review
Article Title	Immunobiology of hepatocarcinogenesis: Ways to go or almost there?
Manuscript Source	Invited Manuscript
All Author List	Pavan Patel, Steven E Schutzer and Nikolaos Pyrsopoulos
Funding Agency and Grant Number
Corresponding Author	Nikolaos Pyrsopoulos, Chief, Division of Gastroenterology and Hepatology, Rutgers-New Jersey Medical School, 185 South Orange Avenue, MSB H538, Newark, NJ 07101-1709, United States. pyrsopni@njms.rutgers.edu
Key Words	Hepatocarcinogenesis; Adoptive cell therapy; Tumorigenesis; Hepatocellular carcinoma; Immunology; Tumorigenesis; Immunotherapy; Immunobiology; Immune checkpoint inhibitors
Core Tip	Hepatocellular carcinoma is on the rise and is associated with high mortality. Cancer immunology is an expanding field with promise. This review will summarize the current concepts in the immunobiology of hepatocarcinogenesis including the interplay of a variety of immune cells involved in anti-tumor and pro-tumor effects. Oncogenic pathways currently known to effect hepatocarcinogenesis will also be discussed. Finally, currently tested and developed treatment modalities employing immunotherapy will be discussed with an outlook on future therapies.
Publish Date	2016-08-10 15:41
Citation	Patel P, Schutzer SE, Pyrsopoulos N. Immunobiology of hepato¬carcinogenesis: Ways to go or almost there? World J Gastrointest Pathophysiol 2016; 7(3): 242-255
URL	http://www.wjgnet.com/2150-5330/full/v7/i3/242.htm
DOI	http://dx.doi.org/10.4291/wjgp.v7.i3.242

Full Article (PDF)	WJGP-7-242.pdf
Full Article (Word)	WJGP-7-242.doc
Manuscript File	26791-Review.doc
Answering Reviewers	26791-Answering reviewers.pdf
Audio Core Tip	26791-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26791-Conflict-of-interest statement.pdf
Copyright License Agreement	26791-Copyright assignment.pdf
Peer-review Report	26791-Peer-review(s).pdf
Scientific Misconduct Check	26791-Scientific misconduct check.pdf
Scientific Editor Work List	26791-Scientific editor work list.pdf