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2/15/2017 1:57:00 PM | Browse: 422 | Download: 765
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Received |
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2016-06-17 08:48 |
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Peer-Review Started |
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2016-06-19 07:45 |
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To Make the First Decision |
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2016-07-27 08:25 |
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Return for Revision |
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2016-07-29 11:56 |
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Revised |
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2016-08-20 02:30 |
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Second Decision |
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2016-11-01 09:43 |
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Accepted by Journal Editor-in-Chief |
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2016-11-01 21:56 |
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Accepted by Company Editor-in-Chief |
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2016-11-17 14:02 |
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Articles in Press |
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2016-11-17 14:03 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-02-09 15:11 |
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Publish the Manuscript Online |
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2017-02-15 08:52 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Engineering, Biomedical |
| Manuscript Type |
Basic Study |
| Article Title |
Evaluation of a chitosan-polyethylene glycol paste as a local antibiotic delivery device
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Cheyenne S Rhodes, Christopher M Alexander, Joel M Berretta, Harry S Courtney, Karen E Beenken, Mark S Smeltzer, Joel D Bumgardner, Warren O Haggard and J Amber Jennings |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health |
R01AR066050 |
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| Corresponding Author |
Christopher M Alexander, Graduate Research Assistant, Department of Biomedical Engineering, University of Memphis, 330 Technology Building, Memphis, TN 38152, United States. chris.alexander@memphis.edu |
| Key Words |
Chitosan; Polyethylene glycol; Paste; Local antibiotic delivery; Biofilm; Bacterial infection |
| Core Tip |
The study investigates the efficacy of a chitosan-polyethylene glycol paste as a local antibiotic delivery device to prevent bacterial infection, particularly in high risk, severe musculoskeletal wounds complex in shape and experiencing decreased vascularity. Research focusing on three different paste formulations categorized by the ratio of acidic to neutral components involved in vitro evaluation of the paste cytotoxicity, degradation, antibiotic elution, as well as an in vivo functional infection model evaluating the antimicrobial efficacy of the paste. Preliminary study outcomes demonstrate the potential of a chitosan-polyethylene glycol paste as a local antibiotic delivery device capable of infection prevention. |
| Publish Date |
2017-02-15 08:52 |
| Citation |
Rhodes CS, Alexander CM, Berretta JM, Courtney HS, Beenken KE, Smeltzer MS, Bumgardner JD, Haggard WO, Jennings JA. Evaluation of a chitosan-polyethylene glycol paste as a local antibiotic delivery device. World J Orthop 2017; 8(2): 130-141 |
| URL |
http://www.wjgnet.com/2218-5836/full/v8/i2/130.htm |
| DOI |
http://dx.doi.org/10.5312/wjo.v8.i2.130 |
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