Publication Name	World Journal of Cardiology
Manuscript ID	28343
Country	United States

Received	2016-06-30 11:02
Peer-Review Started	2016-07-01 17:25
To Make the First Decision	2016-08-04 16:21
Return for Revision	2016-08-05 11:00
Revised	2016-09-07 00:00
Second Decision	2016-09-20 15:52
Accepted by Journal Editor-in-Chief	2016-09-20 20:33
Accepted by Executive Editor-in-Chief	2016-10-09 10:36
Articles in Press	2016-10-09 10:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-09 13:46
Publish the Manuscript Online	2016-12-20 10:04

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	Hematological disorders and pulmonary hypertension
Manuscript Source	Invited Manuscript
All Author List	Rajamma Mathew, Jing Huang, Joseph M Wu, John T Fallon and Michael H Gewitz
Funding Agency and Grant Number
Corresponding Author	Rajamma Mathew, MD, Section of Pediatric Cardiology, New York Medical College, Rm A11, Basic Science Building, 15 Dana Rd, Valhalla, NY 10595, United States. rajamma_mathew@nymc.edu
Key Words	Anemia; Hemolysis; Iron homeostasis; Myelofibrosis; Pulmonary hypertension
Core Tip	Oxidant injury, inflammation, impaired nitric oxide bioavailability and coagulopathy that occur in hematological diseases lead to endothelial dysfunction and thrombo-embolism with subsequent development of pulmonary hypertension (PH). In addition, treatment used for these disorders such as immunosuppressive drugs, splenectomy, bone marrow transplantation and radiation therapy are also known to cause endothelial damage and thrombo-embolism leading to PH. Furthermore, there is a causal relationship between vascular and hematopoietic systems. Patients with chronic myeloproliferative diseases are at a risk of developing PH; and the occurrence of myelofibrosis contributing to impaired hematopoiesis is not uncommon in PH.
Publish Date	2016-12-20 10:04
Citation	Mathew R, Huang J, Wu JM, Fallon JT, Gewitz MH. Hematolo­gical disorders and pulmonary hypertension. World J Cardiol 2016; 8(12): 703-718
URL	http://www.wjgnet.com/1949-8462/full/v8/i12/703.htm
DOI	http://dx.doi.org/10.4330/wjc.v8.i12.703

Full Article (PDF)	WJC-8-703.pdf
Full Article (Word)	WJC-8-703.doc
Manuscript File	28343-Review.doc
Answering Reviewers	28343-Answering reviewers.pdf
Audio Core Tip	28343-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	28343-Conflict-of-interest statement.pdf
Copyright License Agreement	28343-Copyright assignment.pdf
Peer-review Report	28343-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	28343-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	28343-Scientific misconduct check.pdf
Scientific Editor Work List	28343-Scientific editor work list.pdf