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12/21/2016 3:37:00 PM | Browse: 1121 | Download: 3326
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Received |
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2016-06-30 10:21 |
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Peer-Review Started |
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2016-07-01 19:07 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2016-09-05 16:12 |
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Revised |
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2016-09-19 19:03 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2016-09-28 11:27 |
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Second Decision by Editor-in-Chief |
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2016-09-28 17:14 |
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Final Decision by Editorial Office Director |
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2016-10-18 16:33 |
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Articles in Press |
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2016-10-18 16:33 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-11-09 11:16 |
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Publish the Manuscript Online |
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2016-11-17 09:57 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Lipofuscins prepared by modification of photoreceptor cells via glycation or lipid peroxidation show the similar phototoxicity
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Alexander Dontsov, Anna Koromyslova, Mikhail Ostrovsky and Natalia Sakina |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Russian Foundation for Basic Research |
15-29-03831 |
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| Corresponding Author |
Natalia Sakina, PhD, Senior Researcher, Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Kosygina st. 4, 119334 Moscow, Russia. nsakina@mail.ru |
| Key Words |
Model lipofuscins; Retinal pigment epithelium; Photoreceptor outer segments; Bisretinoids; Glycation; Lipid peroxidation; Superoxide |
| Core Tip |
The aim of this work is to investigate the influence of different ways of protein-lipid modification of photoreceptor outer segments (POS) on the spectral characteristics and toxicity of lipofuscin. Therefore, model lipofuscins were prepared by protein-lipid modification of POS with products of lipid peroxidation or glycation reaction and the subsequent addition of the fluorophore A2E. The type of photoreceptor modification has no effect on model lipofuscins phototoxicity. |
| Publish Date |
2016-11-17 09:57 |
| Citation |
Dontsov A, Koromyslova A, Ostrovsky M, Sakina N. Lipofuscins prepared by modification of photoreceptor cells via glycation or lipid peroxidation show the similar phototoxicity. World J Exp Med 2016; 6(4): 63-71
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| URL |
http://www.wjgnet.com/2220-315X/full/v6/i4/63.htm |
| DOI |
http://dx.doi.org/10.5493/wjem.v6.i4.63 |
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