Publication Name	World Journal of Gastroenterology
Manuscript ID	28546
Country	Japan

Received	2016-07-05 11:28
Peer-Review Started	2016-07-06 17:46
To Make the First Decision	2016-07-29 16:26
Return for Revision	2016-08-02 15:44
Revised	2016-08-03 11:41
Second Decision	2016-08-17 13:43
Accepted by Journal Editor-in-Chief	2016-08-17 20:47
Accepted by Executive Editor-in-Chief	2016-08-23 17:08
Articles in Press	2016-08-23 17:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-10-17 20:15
Publish the Manuscript Online	2016-10-26 17:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Therapeutics Advances
Article Title	Liver-targeted hydrodynamic gene therapy: Recent advances in the technique
Manuscript Source	Invited Manuscript
All Author List	Takeshi Yokoo, Kenya Kamimura, Hiroyuki Abe, Yuji Kobayashi, Tsutomu Kanefuji, Kohei Ogawa, Ryo Goto, Masafumi Oda, Takeshi Suda and Shuji Terai
Funding Agency and Grant Number	Funding Agency Grant Number Grant-in-Aid for Scientific Research from the Japanese Society for the Promotion of Sciences 26860354 Grant-in-Aid for Scientific Research from the Japanese Society for the Promotion of Sciences 16K19333 Grant-in-Aid for Scientific Research from the Japanese Society for the Promotion of Sciences 26293175
Corresponding Author	Kenya Kamimura, MD, PhD, Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachido-ri, Chuo-ku, Niigata 951-8510, Japan. kenya-k@med.niigata-u.ac.jp
Key Words	Gene therapy; Liver; Hydrodynamic gene delivery; Non-viral; Image-guided
Core Tip	Among a number of nonviral vector systems, hydrodynamic gene delivery has been used to study human diseases. The major advantage of the method is the simple and easy step to deliver naked DNA into living animal cells by physical force. The original method modification of injecting the DNA solution into a rodent tail vein has made it applicable in large animals. This method of delivering naked DNA can contribute to treat, not only liver disease but also other systemic diseases that can be cured by facilitating/altering gene expression through the liver.
Publish Date	2016-10-26 17:34
Citation	Yokoo T, Kamimura K, Abe H, Kobayashi Y, Kanefuji T, Ogawa K, Goto R, Oda M, Suda T, Terai S. Liver-targeted hydrodynamic gene therapy: Recent advances in the technique. World J Gastroenterol 2016; 22(40): 8862-8868
URL	http://www.wjgnet.com/1007-9327/full/v22/i40/8862.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i40.8862

Full Article (PDF)	WJG-22-8862.pdf
Full Article (Word)	WJG-22-8862.doc
Manuscript File	28546-Review.docx
Answering Reviewers	28546-Answering reviewers.pdf
Audio Core Tip	28546-Audio core tip.wma
Conflict-of-Interest Disclosure Form	28546-Conflict-of-interest statement.pdf
Copyright License Agreement	28546-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	28546-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	28546-Language certificate.pdf
Supplementary Material	Supplementary_Material_20160704193150.pdf
Peer-review Report	28546-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	28546-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	28546-Scientific misconduct check.pdf
Scientific Editor Work List	28546-Scientific editor work list.pdf