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9/28/2016 3:09:00 PM | Browse: 224 | Download: 544
Publication Name World Journal of Pharmacology
Manuscript ID 28886
Country of Manuscript Source United Kingdom
Received
2016-07-19 19:03
Peer-Review Started
To Make the First Decision
2016-07-21 17:17
Return for Revision
2016-07-21 18:16
Revised
2016-07-26 01:56
Second Decision
2016-08-25 19:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-08-31 12:15
Articles in Press
2016-08-31 12:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-09-02 12:33
Publish the Manuscript Online
2016-09-05 15:41
ISSN 2220-3192 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Pharmacology and Pharmacy
Manuscript Type Observational Study
Article Title Innovate combination of sevoflurane dilution in dimethyl sulfoxide: A stability study by gas chromatography and nuclear magnetic resonance
Manuscript Source Invited Manuscript
All Author List F Dámaso Fernández-Ginés, Sergio García-Muñoz, Héctor Mateo-Carrasco, Miguel Ángel Rincón-Cervera, Manuel Cortiñas-Sáenz, José Antonio Morales-Molina, Carmen Fernández-Sánchez, Juan Miguel Expósito-López and Ignacio Rodríguez-García
Funding Agency and Grant Number
Correspondence To Héctor Mateo-Carrasco, MPharm, PhD, MRPharmS, Specialist Pharmacist Cancer Services, Aseptic Services Unit, Department of Pharmacy, Northampton General Hospital, Cliftonville Road, Northampton NN1 5BD, United Kingdom. hector.mateo-carrasco@ngh.nhs.uk
Keywords Sevoflurane; Dimethyl sulfoxide; Uclear magnetic resonance; Gas chromatography; Skin ulcers; Drug stability
Core Tip Direct topical application of anesthetic sevoflurane has recently shown beneficial properties in the management of chronic vascular ulcers. A more convenient formulation could be obtained using solutions of sevoflurane in a miscible solvent such as dimethyl sulfoxide. However, no study has yet assessed the physicochemical and pharmaceutical stability of these formulations. Different concentrations of sevoflurane in dimethyl sulfoxide were stored over 45 d at -10 ℃, 4 ℃ and 25 ℃ and assayed by gas chromatography with a flame ionization detector and nuclear magnetic resonance, showing that molecular structures remained unaltered after exposure to a range of temperatures.
Publish Date 2016-09-05 15:41
Citation Fernández-Ginés FD, García-Muñoz S, Mateo-Carrasco H, Rincón-Cervera MÁ, Cortiñas-Sáenz M, Morales-Molina JA, Fernández-Sánchez C, Expósito-López JM, Rodríguez-García I. Innovate combination of sevoflurane dilution in dimethyl sulfoxide: A stability study by gas chromatography and nuclear magnetic resonance. World J Pharmacol 2016; 5(3): 59-67
Url http://www.wjgnet.com/2220-3192/full/v5/i3/59.htm
DOI http://dx.doi.org/10.5497/wjp.v5.i3.59
Full Article (PDF) WJP-5-59.pdf
Full Article (Word) WJP-5-59.doc
Revised Manuscript 28886-Review.docx
Peer-review Report 28886-Peer-review(s).pdf
Answering Reviewers 28886-Answering reviewers.pdf
Scientific Misconduct Check 28886-Scientific misconduct check.pdf
Scientific Editor Work List 28886-Scientific editor work list.pdf
Audio Core Tip 28886-Audio core tip.aac
Biostatistics Review Certificate 28886-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 28886-Conflict-of-interest statement.pdf
Copyright License Agreement 28886-Copyright assignment.pdf
Data Sharing Statement 28886-Data sharing statement.pdf
Institutional Review Board Approval Form or Document 28886-Institutional review board statement.pdf