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9/28/2016 3:09:00 PM | Browse: 1228 | Download: 2053
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Received |
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2016-07-19 19:03 |
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Peer-Review Started |
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To Make the First Decision |
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2016-07-21 17:17 |
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Return for Revision |
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2016-07-21 18:16 |
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Revised |
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2016-07-26 01:56 |
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Second Decision |
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2016-08-25 19:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2016-08-31 12:15 |
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Articles in Press |
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2016-08-31 12:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-09-02 12:33 |
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Publish the Manuscript Online |
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2016-09-05 15:41 |
| ISSN |
2220-3192 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Observational Study |
| Article Title |
Innovate combination of sevoflurane dilution in dimethyl sulfoxide: A stability study by gas chromatography and nuclear magnetic resonance
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| Manuscript Source |
Invited Manuscript |
| All Author List |
F Dámaso Fernández-Ginés, Sergio García-Muñoz, Héctor Mateo-Carrasco, Miguel Ángel Rincón-Cervera, Manuel Cortiñas-Sáenz, José Antonio Morales-Molina, Carmen Fernández-Sánchez, Juan Miguel Expósito-López and Ignacio Rodríguez-García |
| Funding Agency and Grant Number |
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| Corresponding Author |
Héctor Mateo-Carrasco, MPharm, PhD, MRPharmS, Specialist Pharmacist Cancer Services, Aseptic Services Unit, Department of Pharmacy, Northampton General Hospital, Cliftonville Road, Northampton NN1 5BD, United Kingdom. hector.mateo-carrasco@ngh.nhs.uk |
| Key Words |
Sevoflurane; Dimethyl sulfoxide; Uclear magnetic resonance; Gas chromatography; Skin ulcers; Drug stability |
| Core Tip |
Direct topical application of anesthetic sevoflurane has recently shown beneficial properties in the management of chronic vascular ulcers. A more convenient formulation could be obtained using solutions of sevoflurane in a miscible solvent such as dimethyl sulfoxide. However, no study has yet assessed the physicochemical and pharmaceutical stability of these formulations. Different concentrations of sevoflurane in dimethyl sulfoxide were stored over 45 d at -10 ℃, 4 ℃ and 25 ℃ and assayed by gas chromatography with a flame ionization detector and nuclear magnetic resonance, showing that molecular structures remained unaltered after exposure to a range of temperatures. |
| Publish Date |
2016-09-05 15:41 |
| Citation |
Fernández-Ginés FD, García-Muñoz S, Mateo-Carrasco H, Rincón-Cervera MÁ, Cortiñas-Sáenz M, Morales-Molina JA, Fernández-Sánchez C, Expósito-López JM, Rodríguez-García I. Innovate combination of sevoflurane dilution in dimethyl sulfoxide: A stability study by gas chromatography and nuclear magnetic resonance. World J Pharmacol 2016; 5(3): 59-67 |
| URL |
http://www.wjgnet.com/2220-3192/full/v5/i3/59.htm |
| DOI |
http://dx.doi.org/10.5497/wjp.v5.i3.59 |
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