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3/2/2017 3:36:00 PM | Browse: 1162 | Download: 2273
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Received |
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2016-08-12 09:07 |
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Peer-Review Started |
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2016-08-16 15:42 |
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To Make the First Decision |
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2016-09-26 08:46 |
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Return for Revision |
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2016-09-28 17:08 |
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Revised |
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2016-10-12 22:24 |
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Second Decision |
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2016-12-06 10:57 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-12-14 17:19 |
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Articles in Press |
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2016-12-14 17:19 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-02-28 16:18 |
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Publish the Manuscript Online |
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2017-03-02 12:24 |
| ISSN |
2219-2816 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Urology & Nephrology |
| Manuscript Type |
Observational Study |
| Article Title |
Urine chemokine levels correlate with treatment response to phosphodiesterase 4 inhibitor in prostatitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Pradeep Tyagi, Kim Killinger, Gregory McLennan, Nirmal Jayabalan, Michael Chancellor and Kenneth M Peters |
| Funding Agency and Grant Number |
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| Corresponding Author |
Pradeep Tyagi, PhD, Associate Professor, Department of Urology, University of Pittsburgh School of Medicine, Suite 700 Kaufmann Medical Building, 3471 Fifth Avenue, Pittsburgh, PA 15213, United States. tyagip@upmc.edu |
| Key Words |
Chronic prostatitis; Longitudinal measurement; Phosphodiesterase 4; Urine; Chronic pelvic pain syndrome; Chemokines |
| Core Tip |
Chronic prostatitis or chronic pelvic pain syndrome is a poorly understood and prevalent male condition, which is generally described by pelvic pain in the absence of demonstrable urinary or genital tract infection. Inflammation is considered to play a critical role in the prostatitis and so we carried out a small physician initiated clinical study to investigate the potential efficacy of a new phosphodiesterase 4 inhibitor drug, Apremilast. Urine was collected from the study participants at the baseline and at each visit to assay the chemokine levels and then determine their association with the treatment response. We are the first to report that chemokine levels in urine instead of the semen or prostatic secretions have the potential to serve as non-invasive biomarkers of severity and treatment response of the prostatitis patients. |
| Publish Date |
2017-03-02 12:24 |
| Citation |
Tyagi P, Killinger K, McLennan G, Jayabalan N, Chancellor M, Peters KM. Urine chemokine levels correlate with treatment response to phosphodiesterase 4 inhibitor in prostatitis. World J Clin Urol 2017; 6(1): 18-26 |
| URL |
http://www.wjgnet.com/2219-2816/full/v6/i1/18.htm |
| DOI |
http://dx.doi.org/10.5410/wjcu.v6.i1.18 |
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