Publication Name	World Journal of Radiology
Manuscript ID	29571
Country	Italy

Received	2016-08-20 14:13
Peer-Review Started	2016-08-23 14:22
To Make the First Decision	2016-10-21 08:55
Return for Revision	2016-10-21 10:54
Revised	2016-11-02 19:45
Second Decision	2016-11-17 16:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-11-29 08:55
Articles in Press	2016-11-29 08:55
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-12-05 10:07
Typeset the Manuscript	2017-02-23 10:27
Publish the Manuscript Online	2017-02-27 18:20

ISSN	1949-8470 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Editorial
Article Title	Evaluation of response to immune checkpoint inhibitors: Is there a role for positron emission tomography?
Manuscript Source	Invited Manuscript
All Author List	Matteo Bauckneht, Roberta Piva, Gianmario Sambuceti, Francesco Grossi and Silvia Morbelli
Funding Agency and Grant Number
Corresponding Author	Silvia Morbelli, MD, PhD, Nuclear Medicine Unit, IRCCS San Martino-IST, University of Genoa, Largo R. Benzi 10, 16132 Genova, Italy. silviadaniela.morbelli@hsanmartino.it
Key Words	Immune checkpoint inhibitors; Positron emission tomography; Computed tomography; 18F-fluoro-2-deoxy-D-glucose; Non-18F-fluoro-2-deoxy-D-glucose tracers
Core Tip	In the clinical practice, the radiological interpretation of immunotherapy effects represents a huge challenge at single patient level. However, although the computed tomography-based response evaluation for immune checkpoint inhibitors (ICPIs) is feasible thanks to the introduction of immune-related response criteria, very few data are available for the potential role of 18F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET). Due to the intrinsic nature of FDG accumulation pathophysiology, it might be central to test the complex and variegated response to ICPIs by means of PET. Finally, PET might offer a new insight into the biology of ICPIs thanks to a growing number of non-invasive immune-diagnostic approaches based on non-FDG tracers.
Publish Date	2017-02-27 18:20
Citation	Bauckneht M, Piva R, Sambuceti G, Grossi F, Morbelli S. Evaluation of response to immune checkpoint inhibitors: Is there a role for positron emission tomography? World J Radiol 2017; 9(2): 27-33
URL	http://www.wjgnet.com/1949-8470/full/v9/i2/27.htm
DOI	http://dx.doi.org/10.4329/wjr.v9.i2.27

Full Article (PDF)	WJR-9-27.pdf
Full Article (Word)	WJR-9-27.doc
Manuscript File	29571-Review.docx
Answering Reviewers	29571-Answering reviewers.pdf
Audio Core Tip	29571-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	29571-Conflict-of-interest statement.pdf
Copyright License Agreement	29571-Copyright assignment.pdf
Peer-review Report	29571-Peer-review(s).pdf
Scientific Misconduct Check	29571-Scientific misconduct check.pdf
Scientific Editor Work List	29571-Scientific editor work list.pdf