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Publication Name World Journal of Hypertension
Manuscript ID 29857
Country of Manuscript Source Japan
2016-08-29 20:16
Peer-Review Started
2016-08-29 22:56
To Make the First Decision
2016-11-11 09:04
Return for Revision
2016-11-21 15:46
2016-12-22 09:37
Second Decision
2017-01-22 16:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-02-13 12:12
Articles in Press
2017-02-13 12:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-04-28 16:57
Publish the Manuscript Online
2017-05-03 14:34
ISSN 2220-3168 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Cardiac and Cardiovascular Systems
Manuscript Type Observational Study
Article Title Association between G-protein β3 subunit gene and isolated systolic blood pressure elevation of greater than 130 mmHg: A large-scale cross-sectional study in the Japanese population
Manuscript Source Invited Manuscript
All Author List Masahiko Eto, Taro Takeshima, Masanori Harada, Shinji Fujiwara, Maki Kumada, Toyomi Kamesaki, Kazuhiro Takamura, Tsuneaki Kenzaka, Yoshikazu Nakamura, Takanori Aonuma, Masanobu Okayama and Eiji Kajii
Funding Agency and Grant Number
Funding Agency Grant Number
Jichi Medical University 21st Century Center of Excellence Program from Minister Education, Culture, Sports, Science and Technology in Japan
Corresponding author Masanobu Okayama, MD, PhD, Division of Community Medicine and Medical Education, Kobe University Graduate School of Medicine, 2-1-5 Arata-sho, Hyogo-ku, Kobe 652-0032, Hyogo, Japan. okayama@jichi.ac.jp
Keywords Prehypertension; Hypertension; G-protein β3 subunit gene; Single nucleotide polymorphism
Core Tip The association of GNB3 gene polymorphism with hypertension has been examined in different populations. Unfortunately, the reported results have been controversial. This large-scale cross-sectional study of the Japanese population clarifies that among males aged ≤ 49 years, the TT single nucleotide polymorphism of GNB3 C825T is significantly associated with high systolic blood pressure (SBP) (≥ 130 mmHg). Therapeutic intervention is recommended at this level of SBP to prevent cardiovascular disease and its progression to hypertension. This approach is likely to be more effective for youngsters, compared to the elderly. This study suggests that using genetic information could make this approach more effective.
Publish Date 2017-05-03 14:34
Citation Eto M, Takeshima T, Harada M, Fujiwara S, Kumada M, Kamesaki T, Takamura K, Kenzaka T, Nakamura Y, Aonuma T, Okayama M, Kajii E. Association between G-protein β3 subunit gene and isolated systolic blood pressure elevation of greater than 130 mmHg: A large-scale cross-sectional study in the Japanese population. World J Hypertens 2017; 7(2): 24-31
Url http://www.wjgnet.com/2220-3168/full/v7/i2/24.htm
DOI http://dx.doi.org/10.5494/wjh.v7.i2.24
Full Article (PDF) WJH-7-24.pdf
Full Article (Word) WJH-7-24.doc
Manuscript File 29857-Review.docx
Answering Reviewers 29857-Answering reviewers.pdf
Audio Core Tip 29857-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 29857-Conflict-of-interest statement.pdf
Copyright License Agreement 29857-Copyright assignment.pdf
Data Sharing Statement 29857-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 29857-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160828210814.docx
Institutional Review Board Approval Form or Document 29857-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 29857-Language certificate.pdf
Peer-review Report 29857-Peer-review(s).pdf
Scientific Misconduct Check 29857-Scientific misconduct check.pdf
Scientific Editor Work List 29857-Scientific editor work list.pdf