Publication Name	World Journal of Gastroenterology
Manuscript ID	30466
Country	United States

Received	2016-10-06 20:00
Peer-Review Started	2016-10-07 19:48
To Make the First Decision	2016-10-28 09:15
Return for Revision	2016-10-31 14:20
Revised	2016-12-06 10:45
Second Decision	2016-12-16 17:22
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-12-21 16:13
Articles in Press	2016-12-21 16:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-03-03 14:30
Publish the Manuscript Online	2017-03-13 19:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Systematic Reviews
Article Title	Microbiome and pancreatic cancer: A comprehensive topic review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Natalie Ertz-Archambault, Paul Keim and Daniel Von Hoff
Funding Agency and Grant Number
Corresponding Author	Natalie Ertz-Archambault, MD, Department of Internal Medicine, Mayo School of Graduate Medical Education, Mayo Clinic Arizona, 13400 E Shea Blvd, Scottsdale, AZ 85259, United States. ertz.natalie@mayo.edu
Key Words	Pancreatic Cancer; Human microbiome; Biomarkers; cancer; Cancer screening tests; Treatment effectiveness
Core Tip	Recent literature reports influences of microbiome alterations contributing to carcinogenesis of pancreatic cancer. The poor prognostics of pan-creatic cancer are related to late recognition and treatment resistance, thus warranting investigations for modifiable risk factors, early screening biomarkers, and microenvironment elements that affect outcomes. Learning the role of microbiome in carcinogenesis may lead to identifying reliable, non-invasive screening strategies, and additional modifiable risk factors. Microbiome studies in pancreatic cancer could offer therapeutic targets and an extraordinary opportunity to favorably transform cancer response to existing treatment protocols and improve survival by reduction of cancer-related cachexia by manipulating human gut microbiota.
Publish Date	2017-03-13 19:06
Citation	Ertz-Archambault N, Keim P, Von Hoff D. Microbiome and pancreatic cancer: A comprehensive topic review of literature. World J Gastroenterol 2017; 23(10): 1899-1908
URL	http://www.wjgnet.com/1007-9327/full/v23/i10/1899.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i10.1899

Full Article (PDF)	WJG-23-1899.pdf
Full Article (Word)	WJG-23-1899.doc
Manuscript File	30466-Review.docx
Answering Reviewers	30466-Answering reviewers.pdf
Audio Core Tip	30466-Audio core tip.m4a
Biostatistics Review Certificate	30466-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	30466-Conflict-of-interest statement.pdf
Copyright License Agreement	30466-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	30466-Institutional review board statement.pdf
Peer-review Report	30466-Peer-review(s).pdf
Scientific Misconduct Check	30466-Scientific misconduct check.pdf
Scientific Editor Work List	30466-Scientific editor work list.pdf