Publication Name	World Journal of Gastroenterology
Manuscript ID	30569
Country	Japan

Received	2016-10-08 16:11
Peer-Review Started	2016-10-11 09:34
To Make the First Decision	2016-10-28 13:19
Return for Revision	2016-11-02 18:55
Revised	2016-11-17 00:21
Second Decision	2017-03-13 14:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-03-15 12:10
Articles in Press	2017-03-15 12:10
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-03-29 03:10
Typeset the Manuscript	2017-04-21 12:05
Publish the Manuscript Online	2017-05-15 06:16

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Platelets in liver disease, cancer and regeneration
Manuscript Source	Invited Manuscript
All Author List	Tomohiro Kurokawa and Nobuhiro Ohkohchi
Funding Agency and Grant Number
Corresponding Author	Nobuhiro Ohkohchi, Professor, De­partment of Surgery, Division of Gastroenterological and Hepatobiliary Surgery, and Organ Transplantation, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan. nokochi3@md.tsukuba.ac.jp
Key Words	Platelet; liver cirrhosis; Liver regeneration; Cancer; thrombopoietin; Thrombopoietin agonist; Eltrombopag
Core Tip	Platelets improve liver fibrosis and accelerate liver regeneration; therefore, patients with liver dysfunction due to chronic liver disease (CLD) and cirrhosis can benefit from platelet transfusion. However, administration of the thrombopoietin receptor agonist eltrombopag for 6 mo did not result in the improvement of liver function in patients with CLD despite its long-term safety and ability to maintain an increased platelet count. We believe that this difference is due to platelet aging. Therefore, we are pursuing novel strategies with thrombopoietin receptor agonists and desialylated formulations to treat liver diseases.
Publish Date	2017-05-15 06:16
Citation	Kurokawa T, Ohkohchi N. Platelets in liver disease, cancer and regeneration. World J Gastroenterol 2017; 23(18): 3228-3239
URL	http://www.wjgnet.com/1007-9327/full/v23/i18/3228.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i18.3228

Full Article (PDF)	WJG-23-3228.pdf
Full Article (Word)	WJG-23-3228.doc
Manuscript File	30569-Review.docx
Answering Reviewers	30569-Answering reviewers.pdf
Audio Core Tip	30569-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	30569-Conflict-of-interest statement.pdf
Copyright License Agreement	30569-Copyright assignment.PDF
Non-Native Speakers of English Editing Certificate	30569-Language certificate.pdf
Peer-review Report	30569-Peer-review(s).pdf
Scientific Misconduct Check	30569-Scientific misconduct check.pdf
Scientific Editor Work List	30569-Scientific editor work list.pdf