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Publication Name World Journal of Virology
Manuscript ID 31125
Country of Manuscript Source Spain
Received
2016-10-31 11:10
Peer-Review Started
2016-11-03 17:20
To Make the First Decision
2016-12-01 14:39
Return for Revision
2016-12-07 08:31
Revised
2016-12-20 16:14
Second Decision
2017-01-18 11:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-02-13 13:54
Articles in Press
2017-02-13 13:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-05-06 20:00
Publish the Manuscript Online
2017-05-12 22:16
ISSN 2220-3249 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Allergy
Manuscript type Observational Study
Article Title Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients
Manuscript Source Invited Manuscript
All Author List Julio Collazos, Eulalia Valle-Garay, Tomás Suárez-Zarracina, Angel-Hugo Montes, José A Cartón and Víctor Asensi
Funding Agency and Grant Number
Funding Agency Grant Number
the Oviedo University research grants UNIOV-12-MA-03
the Oviedo University research grants SV-PA-13-ECOEMP-57
Correspondence To Dr. Julio Collazos, Infectious Diseases Unit, Hospital de Galdácano, Bº Labeaga s/n, 48960 Vizcaya, Spain. med003033@gmail.com
Keywords Human immunodeficiency virus; Hepatitis C virus; Liver fibrosis; Transient elastometry; Non-invasive fibrosis markers; Metalloproteases; Their tissue inhibitors; Genetic polymorphisms
Core Tip The role of matrix metalloproteases (MMPs) and their tissue inhibitors (TIMPs) in the development of liver fibrosis is uncertain. We determined some single nucleotide polymorphisms (SNPs), as well as the serum levels of diverse MMPs and TIMPs, in non-alcoholic, human immunodeficiency virus-infected patients with/out hepatitis C virus coinfection, to evaluate their possible relationship with liver fibrosis as assessed by transient elastometry. MMP-2 was independently associated with significant fibrosis. Likewise, MMP-2, TIMP-2 and MMP-9 were independent predictors of transient elastometry values and of other non-invasive tests of fibrosis. No SNP was significantly associated with liver fibrosis. Our findings support the value of these markers in the evaluation of fibrosis.
Publish Date 2017-05-12 22:16
Citation Collazos J, Valle-Garay E, Suárez-Zarracina T, Montes AH, Cartón JA, Asensi V. Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients. World J Virol 2017; 6(2): 36-45
Url http://www.wjgnet.com/2220-3249/full/v6/i2/36.htm
DOI http://dx.doi.org/10.5501/wjv.v6.i2.36
Full Article (PDF) WJV-6-36.pdf
Full Article (Word) WJV-6-36.doc
Manuscript File 31125-Review.docx
Answering Reviewers 31125-Answering reviewers.pdf
Audio Core Tip 31125-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 31125-Conflict-of-interest statement.pdf
Copyright License Agreement 31125-Copyright assignment.pdf
Data Sharing Statement 31125-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 31125-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 31125-Institutional review board statement.pdf
Scientific Research Process 31125-Scientific research process.pdf
Peer-review Report 31125-Peer-review(s).pdf
Scientific Misconduct Check 31125-Scientific misconduct check.pdf
Scientific Editor Work List 31125-Scientific editor work list.pdf