Publication Name	World Journal of Radiology
Manuscript ID	31150
Country	United States

Received	2016-11-01 09:15
Peer-Review Started	2016-11-02 21:53
First Decision by Editorial Office Director
Return for Revision	2016-12-15 11:38
Revised	2016-12-20 02:18
Publication Fee Transferred
Second Decision by Editor	2017-01-04 16:07
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2017-01-14 14:08
Articles in Press	2017-01-14 14:08
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-03-21 10:31
Publish the Manuscript Online	2017-03-24 09:48

ISSN	1949-8470 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Observational Study
Article Title	Multimodality imaging using proton magnetic resonance spectroscopic imaging and 18F-fluorodeoxyglucose-positron emission tomography in local prostate cancer
Manuscript Source	Invited Manuscript
All Author List	Amita Shukla-Dave, Cecilia Wassberg, Darko Pucar, Heiko Schöder, Debra A Goldman, Yousef Mazaheri, Victor E Reuter, James Eastham, Peter T Scardino and Hedvig Hricak
Funding Agency and Grant Number	Funding Agency Grant Number National Institutes of Health grant R01 CA76423 NIH/NCI Cancer Center Support Grant P30 CA008748
Corresponding Author	Amita Shukla-Dave, PhD, Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, United States. davea@mskcc.org
Key Words	Proton magnetic resonance spectroscopic imaging; <sup>18</sup>F-fluorodeoxyglucose-positron emission tomography; Prostate cancer
Core Tip	Although metabolic imaging is increasingly utilized in prostate cancer (PCa), the mechanisms leading to cancer-related metabolic rearrangements and consequent imaging findings remain poorly understood. This study compared two modalities utilizing distinct metabolic pathways, proton magnetic resonance spectroscopic imaging (1H-MRSI) and 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT), in local PCa. Abnormal intermediary metabolism on 1H-MRSI was present in 21/22 patients, while abnormal glycolysis on 18F-FDG-PET/CT was detected in only 3/22 patients. This study provides an insight why metabolic PET agents promising for detection of PCa target intermediary metabolism. On the other hand, elevated glycolysis may have ominous prognostic implications in PCa.
Publish Date	2017-03-24 09:48
Citation	Shukla-Dave A, Wassberg C, Pucar D, Schöder H, Goldman DA, Mazaheri Y, Reuter VE, Eastham J, Scardino PT, Hricak H. Multimodality imaging using proton magnetic resonance spectroscopic imaging and 18F-fluorodeoxyglucose-positron emission tomography in local prostate cancer. World J Radiol 2017; 9(3): 134-142
URL	http://www.wjgnet.com/1949-8470/full/v9/i3/134.htm
DOI	http://dx.doi.org/10.4329/wjr.v9.i3.134

Full Article (PDF)	WJR-9-134.pdf
Full Article (Word)	WJR-9-134.doc
Manuscript File	31150-Review.docx
Answering Reviewers	31150-Answering reviewers.pdf
Audio Core Tip	31150-Audio core tip.mp3
Biostatistics Review Certificate	31150-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	31150-Conflict-of-interest statement.pdf
Copyright License Agreement	31150-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20161031230008.docx
Institutional Review Board Approval Form or Document	31150-Institutional review board statement.pdf
Peer-review Report	31150-Peer-review(s).pdf
Scientific Misconduct Check	31150-Scientific misconduct check.pdf
Scientific Editor Work List	31150-Scientific editor work list.pdf